SKU: 21403797289

mNSET™ (Non-Surgical Embryo Transfer) Device for Mice 60010 (10 Devices per box)

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Ships within 48 hours · Estimated delivery Aug 18 - Aug 23

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Description

mNSET™ (Non-Surgical Embryo Transfer) Device for Mice 60010 (10 Devices per box)mNSET ordered after June 24, 2026 will ship on July 7, 2026 For AI and pathogen transfer, see product 60020. 10 Devices Box ParaTechs mNSET (Non Surgical Embryo Transfer) Device for Mice 60010 revolutionizes mouse uterine embryo transfer by reducing cost and eliminates the need for animal anesthesia and recovery normally required for conventional surgical procedures. Compare this methodology with the time, expense, and training required to accomplish

mNSET ordered after June 24, 2026 will ship on July 7, 2026

For AI and pathogen transfer, see product 60020.

10 Devices/Box

ParaTechs’ mNSET™ (Non-Surgical Embryo Transfer) Device for Mice 60010 revolutionizes mouse uterine embryo transfer by reducing cost and eliminates the need for animal anesthesia and recovery normally required for conventional surgical procedures. Compare this methodology with the time, expense, and training required to accomplish the same task with other methods and you will discover that the NSET procedure is humane, quick, and cost effective.

The mNSET Device for Mice 60010 is manufactured in the USA, solely for ParaTechs Corporation, and is EtO (Ethylene Oxide) sterilization processed. Patent Information: Non-Surgical Embryo Transfer Method and Apparatus, United States Patent 9,615,903. [PDF]

 Harmonized Tariff: 3926.90.9910

Based on user feedback, we would like to emphasize the following observation: 

The mNSET hub must be firmly seated on the P2 pipette to effectively uptake and dispense liquid.  Please be sure to firmly attach the device using pressure and a slight twisting motion.  This will ensure proper placement.

10% Discount on orders of 10 or more boxes. Discount applies automatically at checkout. 


mNSET 60010 Videos

Watch the mouse NSET demonstration videos:

  1. mNSET 60010 Full Procedure Demonstration Video
  2. mNSET 60010 Quick Procedure Only Video

Watch ParaTechs' JoVE article "Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination"  

  1. Author Spotlight
  2. Cervical Manipulation Procedure for Use with Artificial Insemination in CD1 Mice (CM Rod 90050) (mC&I Device 60020)
  3. Non-Surgical Embryo Transfer Procedure for Use with Cervical Manipulation in CD1 Mice (CM Rod 90050) (mNSET Device 60010)

Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination JoVE Published: July 7, 2023

mNSET 60010 Webinars

Watch both webinars presented by Dr. Barbara Stone, Director of Rodent Assisted Reproductive Technologies, ParaTechs Corporation

  1. Rodent Embryo Transfer and the 3Rs
  2. The Future of Mouse Embryo Transfer: Achieving the 3Rs with the NSET Device

Labroots Webinar ABSTRACT: Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for transfer of embryos into the uterine horn of mice, surgery is expensive, time consuming, and requires technical expertise. Surgery is also a stressful procedure for the mouse, which has to be anesthetized and treated with an analgesic. We have developed a simple, brief procedure for ET using a non-surgical embryo transfer (NSET) device. Once embryos are loaded into the NSET device, the NSET catheter passes through the vagina and traverses the cervix to deposit the embryos into the uterine horn of a recipient mouse. Since the NSET procedure does not require sedation, opening of the inner body cavity, or use of an analgesic, this procedure is less stressful for the mouse than surgery. In proof, our results show that when pseudopregnant mice are monitored by electrocardiography, the non-surgical procedure does not affect heart rate. The NSET procedure also has no effect on the level of the stress biomarker fecal corticosterone measured by ELISA analysis. However, surgery or anesthesia does lower heart rate and increases levels of fecal corticosterone. Additional studies show that the NSET procedure is effective for transfer of mouse embryos for the purposes of rederivation, cryorecovery, and transgenic research. Embryos can be successfully transferred with the NSET technique after cryopreservation, in vitro fertilization (IVF), or embryonic stem (ES) cell injection as an alternative to traditional surgical embryo transfer. The NSET device has also successfully transferred mouse sperm for artificial insemination. Therefore, the NSET technique is an example of a 3Rs refinement, an alternative to a surgical procedure, which will lead the way for improved assisted reproductive techniques in mice. 


Uses

Mouse Embryo Transfer:

  • Embryo transfer after DNA microinjection
  • ES cell chimeric blastocyst transfer
  • Cryopreserved embryo transfer
  • Embryo transfer after in vitro fertilization
  • Embryo transfer for rederivation

Other:

  • Small volume material transfer to the uterine horn.  For larger volume transfer, please consider the mC&I device which has a 40µl capacity. 
  • Mouse Sperm Transfer for Artificial Insemination (AI): Fresh sperm
  • Pathogen Transfer: Chlamydia trachomatis
  • Material Transfer:
    • Decidualization procedures
    • Pharmaceuticals

Advantages

  • Eliminates the pain and distress of surgery
  • No anesthesia required
  • Eliminates need for post-surgical monitoring of animals
  • Reduces regulatory burden by eliminating need to justify survival surgery
  • Eliminates surgical instruments and time-consuming pre- and post-surgical processes
  • Greatly reduces time required to become proficient in embryo transfer or artificial insemination (AI)
  • Reduces costs of embryo transfer
  • Reduces costs of AI
  • Easy procedure
  • Convenient
  • Sterile and ready to use
  • 3Rs implementation (Reduce & Refine)

Documents

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 21403797289

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Awesome socks. Has little gel pad on top of heel for no slip. Thin and comfortable. Previously Purchased at Nordstrom rack and no longer in stock. Happy to find here Note: Will shrink a little best to air dry
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Boise, US
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Very good product
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I purchased these to wear inside lowcut slip on casual shoes, I don't particularly like to not wear socks in my shoes for hygienic reasons. Prior to purchasing these socks, all I could find were those made of very light beige hosiery type material , and my slip on shoes would slide around a bit. These are light weight and breathable athletic type material, with a very good gripper strip at the heel. One pair of my slip on casual shoes have a particularly lower cut in the toe area, but the shoe is black and I chose the black color and though I see a hint of the sock there, it matches and does not detract from the look of the casual solid black shoe
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Anna Wylda
Lake Worth, US
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They stay out! No more sock wads!
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Best no show socks ever made!!!!! I've been struggling for 2 years to find ones that actually stay on your foot, even other national brands, and I just became content wearing my sneakers without socks. They ALWAYS slid down into my show & I ended up walking on a wad of sock until I could fix it...or usually just took them off after a couple of tries. Enter Under Armor!!! They a mid weight, but not very thick & still breathable. They work too by actually staying on your foot! Not once have they slid down into my show!! Very comfortable but they could be a little more affordable.
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Belleville, US
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Ive tried so many no show socks but I love these. This is the 3rd set I've bought. They never slip off and the material is thin and breathable. Perfect for working out.
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