SKU: 56693079521

Protein Folding Disorders of the Central Nervous System

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Protein Folding Disorders of the Central Nervous SystemThis exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by

This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.

This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.

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SKU: 56693079521

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4.4 ★★★★★
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rockspawner
Whiting, US
★★★★★ 5
Use boxes
Format: Paperback
Loving this so far but no book will tell you how to import the projects use the boxes on the sides of your pc
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Reviewed in the United States on December 9, 2025
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Arch Stanton
Lake Worth, US
★★★★★ 5
Very Good Godot Book
Format: Paperback
Great book overall! Best suited for beginners as it literally begins by conceptually introducing variables, operators, etc. Still, it's very Godot. And nicely up-to-date as well, focusing on Godot 4.x and GDScript 2. Note though that the book only covers 2D, which is a shame. Hopefuly, the author is hard at work on a text thast starts where this one ends and moves on to explore 3D in Godot. The illustrations are little muddy, but fortunately, Packt offers free downloads of (much crisper) PDFs with proof of purchase.
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Reviewed in the United States on May 25, 2024
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Wolfgang Hendrix
Battle Creek, US
★★★★★ 5
Book Review: "Learning GDScript with Godot 4
Format: Kindle, Format: Kindle
Learning GDScript with Godot 4" is an invaluable resource for both beginners and those looking to solidify their understanding of Godot's scripting language. This comprehensive guide takes you from the very basics to creating portfolio-worthy projects, making it a perfect starting point for aspiring game developers. One of the book's standout features is its in-depth approach. It covers the fundamentals thoroughly, ensuring that readers build a strong foundation in GDScript. The inclusion of numerous code examples is particularly beneficial, providing practical insights into how to implement various features and mechanics within Godot 4. Visual learners will appreciate the thoughtfully placed pictures throughout the book. While not overly abundant, these visuals effectively complement the text, helping to clarify complex concepts and enhance understanding. Despite Godot's increasing support for C#, the focus on GDScript in this book is well-justified. GDScript is tightly integrated with Godot, making it an excellent choice for rapid development and learning. The book's code-centric approach ensures that readers gain hands-on experience, which is crucial for mastering any programming language. Overall, "Learning GDScript with Godot 4" is an excellent resource for anyone looking to learn or deepen their knowledge of GDScript and Godot 4. Its thorough coverage, practical examples, and supportive visuals make it a must-have for your game development library. Whether you're a complete beginner or looking to fill in gaps in your knowledge, this book will guide you every step of the way.
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Reviewed in the United States on May 28, 2024
J
Justin Horner
Birmingham, US
★★★★★ 5
An Excellent Introduction to Game Programming using GDScript/Godot
Format: Paperback
You’ll get up and going quickly with an overview of Godot and then jump straight into GDScript by learning about variables, control flow, collections, loops, object-oriented programming, and concepts like DRY, KISS, etc. Then the fun begins by building game mechanics while learning specifics of Godot such as the node/scene system, reusing scenes, cameras, collision detection, creating user interfaces, and more. It also covers local multiplayer where you'll learn the basics of computer networking followed by learning about built-in multiplayer nodes provided by Godot. The final chapters cover some advanced programming patterns like event bus, object pooling, and state machines. By the end, you’ll have a fully playable single/local multiplayer game in the style of Vampire Survivors! I thoroughly enjoyed my time with this book and highly recommend it for anyone who wants to get started on their journey to learn programming and even for experienced game programmers who want to learn Godot and GDScript.
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Reviewed in the United States on May 19, 2024
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Scrawller on da Waller
Los Angeles, US
★★★★★ 4
Fine so far.
Format: Paperback
I am looking for some of the code from exercises, but can't find it in the project files, and they say don't copy it from the ebook...?
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Reviewed in the United States on November 17, 2024

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