SKU: 14979191633

Mouse Anti-Human HLA-E Antibody (S-3810)

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Description

Mouse Anti-Human HLA-E Antibody (S-3810)Product Specification Host Mouse Antigen HLA E Synonyms HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E; HLA 6. 2; HLAE Location Cell membrane Accession P13747 Clone Number S 3810 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood cells Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability

Product Specification


Host Mouse
Antigen HLA-E
Synonyms HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E; HLA-6.2; HLAE
Location Cell membrane
Accession P13747
Clone Number S-3810
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human peripheral blood cells
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

HLA-E is a non-classical, oligomorphic class Ib major histocompatibility complex (MHC) molecule whose primary function centers on presenting highly conserved nonameric signal peptides (predominantly the VMAPRTLVL sequence, known as VL9) derived from the leader sequences of other classical HLA class I molecules (such as HLA-A, -B, -C, and -G) via a TAP-dependent processing pathway. These peptides form stable peptide-HLA-E-β2m trimers that are transported to the cell membrane, where they serve as key ligands for the CD94/NKG2 family of receptors expressed on NK cells and certain CD8⁺ T cells. Notably, HLA-E exhibits significantly higher affinity for the inhibitory receptor NKG2A than for the activating receptor NKG2C. This mechanism constitutes a real-time "sensing system" that monitors the overall expression levels of classical MHC-I molecules within the cell, enabling the immune system to recognize and eliminate "missing-self" cells—those that have downregulated classical MHC-I due to viral infection or malignant transformation. Unlike classical HLA molecules, HLA-E displays extremely low genetic polymorphism (predominantly represented by the E01:01 and E01:03 alleles), minimal surface expression levels, and a remarkably short half-life (approximately 12 minutes). Its cytoplasmic tail contains a unique lysine/tryptophan motif that drives clathrin-mediated rapid endocytosis via the adaptor protein AP-2, followed by endosomal peptide exchange and recycling through VCP-associated pathways. This unconventional intracellular trafficking mechanism enables HLA-E, under specific conditions (such as macrophages infected with mycobacteria or CMV-vectored vaccine strategies), to load suboptimal peptides derived from stress protein Hsp60 signal sequences or from pathogens including Mycobacterium, Salmonella, HIV, and SARS-CoV-2. These peptides are presented in an HLA-E-restricted manner to CD8⁺ T cells expressing TCRs featuring the unique TRAV17 gene segment, thereby eliciting adaptive immune responses. Given its dual role as both a central hub maintaining NK cell tolerance and a shared target exploited by viruses (such as HCMV and HIV) and tumors (which upregulate HLA-E to retain NK inhibitory signals and evade immunity), HLA-E has emerged as a critical target for developing "universal" T cell/NK cell immunotherapies and for designing novel CMV-vectored vaccines—exemplified by the clearance of SIV in rhesus macaques within the RhCMV/SIV model.

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SKU: 14979191633

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4.2 ★★★★★
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Ninel Bubon
West Palm Beach, US
★★★★★ 5
It is real and natural. No synthetic- no allergy!!!
Size: 2' x 6' (Double Pelt), Color: Brown Tipped
SUPER QUALITY, the color is exactly like on the picture, I love it!!! Thank you!
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Reviewed in the United States on April 3, 2026
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R. L.
Omaha, US
★★★★★ 5
Soft and luxurious, high quality - but don't buy if you have cats
Color: Ivory White, Size: 2' x 6' (Sheepskin Shape)
I give the rug a five-star rating because it deserves it. I was really surprised at how good the rug is right out of the package (it was packaged very well too). Because this rug is relatively less expensive than many other listings of natural sheepskin rugs on Amazon and elsewhere, I wasn't expecting much. But it turned out to be thick, soft, fluffy, plush, and luxurious all over. Many years ago I have purchased another natural sheepskin rug from Amazon described to be of the same size as this one (I got the 2'*6' one), but this one is definitely much bigger in its actual size. It's hands-down a high-quality, high-value purchase if you want a nice natural sheepskin rug. I also love how beautiful the natural creamy white color is. Now, the story takes a turn. It does have a "natural and organic" smell as mentioned in many other reviews. The smell itself is not repulsive. I don't know how long it will take for it to air out (my last rug never really got rid of the smell, but it was not a big issue since I put it on the floor. I lost the rug in cross country moving.) But now I have a cat! My cat just couldn't resist tackling the rug the moment it was laid on the floor. She probably imagined herself to be a lion or a tiger who just caught some big prey. She couldn't stop kicking and biting the rug, trying to tear it apart. She came back to it a few times after breaks already. And this is day one. I am guessing this smell does stimulate some instinctive call from her genes. In a few short moments, she managed to tear off quite some fur from the edge of the rug... The rug still looks fine since I just received it today. I am not sure how long it will last with my cat though. Before ordering, I thought about this possibility and googled whether cats and sheepskin rugs can co-exist. I got many cute picture results showing angelic cats resting contently in the long and soft sheepskin fur, looking totally adorable and peaceful. Many articles say that natural rugs calm our fluffy friends down. Well, I told myself "perfect!" Win-win for me and my cat. Now, here we are, the beginning of my cat's conquest of an imaginary lamb (which was a real lamb.) I cannot even return it since it has already been damaged by my cat... In the worst case, this rug would become a really expensive cat entertainment piece that would eventually be destroyed....:((( I even started feeling guilty for buying animal-based products - but then comforted myself by remembering reading somewhere that cow and lamb leather goods come from animals that would be slaughtered for meat consumption anyways. My cat is already eating canned food containing Australian lamb, etc, etc. Really need to stop the thoughts. So this is my review. Beautiful rug of excellent quality and unbeatable value, unless you have a cat(s).
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Reviewed in the United States on April 3, 2022
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reader2
Lake Worth, US
★★★★★ 5
Good quality, nice looking, cozy
Color: Cream Brown, Size: 2 x 6 ft Sheepskin
Good quality, accurate color. Perfect length for floor beside queen size bed.
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Reviewed in the United States on May 24, 2026
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Kae @treehousebus
Waukegan, US
★★★★★ 5
Perfect for a queen bed
Color: Tan, Size: 2' x 6' (Sheepskin Shape), Color: Tan, Size: 2' x 6' (Sheepskin Shape)
I LOVE this rug. I’m so glad I bought this instead of a cheap dupe. Reasonably priced, arrived quickly, doesn’t smell. It’s super soft and fluffy and really dense, so far I haven’t noticed any shedding. The size is perfect for draping across a queen bed. The color is beautiful and feels very natural. I might buy a second one for my bus conversion! Thank you so much!
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Reviewed in the United States on May 5, 2026
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🤪SillyBanana🍌
Battle Creek, US
★★★★★ 5
It's perfect!
Color: Snow Grey, Size: 2' x 3' (Sheepskin Shape)
Gorgeous and soft! We love it! Very quality fur.
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Reviewed in the United States on April 20, 2026

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