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Description
Biotinylated Nucleolin/NCL His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms Protein C23 Accession P19338 1 Amino Acid Sequence Val2 Glu710 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 90 100kDa (Reducing) Purity 85% by SDS PAGE Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | Protein C23 |
| Accession | P19338-1 |
| Amino Acid Sequence | Val2-Glu710 with His&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-100kDa (Reducing) |
| Purity | ＞85% by SDS-PAGE |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Yang L, Niu K, Wang J, Shen W, Jiang R, Liu L, Song W, Wang X, Zhang X, Zhang R, Wei D, Fan M, Jia L, Tao K. Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD. J Hepatol. 2024 Oct;81(4):651-666. |
Background
Nucleolin (NCL) is a crucial multifunctional nucleolar protein in eukaryotic cells, possessing nucleo-cytoplasmic shuttling capability. Its three distinctive structural domains enable it to induce chromatin decondensation by binding to histone H1 and to specifically recognize RNA sequences (with higher affinity for 5'-UUAGGG-3' repeats than their DNA counterparts). This protein not only participates in fundamental biological processes such as ribosome biogenesis, pre-rRNA transcription and processing, and transcriptional elongation regulation, but is also extensively involved in cell proliferation, apoptosis regulation, and stress response. Under pathological conditions, through its roles in tumorigenesis and viral infection, nucleolin has emerged as a significant potential target for anti-tumor and anti-viral therapies.
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