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Description
Alexa Fluor® 488 Mouse Anti-Human CD95 Antibody (S-3025)Product Specification Host Mouse Antigen CD95 Synonyms Tumor necrosis factor receptor superfamily member 6; Apo 1 antigen; Apoptosis mediating surface antigen FAS; FASLG receptor; APT1; FAS1; TNFRSF6; FAS Location Cell membrane Accession P25445 Clone Number S 3025 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical
Product Specification
| Host | Mouse |
| Antigen | CD95 |
| Synonyms | Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; APT1; FAS1; TNFRSF6; FAS |
| Location | Cell membrane |
| Accession | P25445 |
| Clone Number | S-3025 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD95, also known as Fas or APO-1, is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. It is a member of the tumor necrosis factor receptor superfamily and is expressed on the surface of various immune cells, including T cells and B cells. When CD95 is engaged by its ligand, CD95L, it triggers a signaling cascade involving the recruitment of adaptor proteins such as FADD, which in turn activates caspases, leading to the dismantling of the cell. This pathway is essential for maintaining immune homeostasis by eliminating activated or damaged cells. Dysregulation of CD95 signaling has been implicated in a range of diseases, including autoimmune disorders and cancer, highlighting its importance in both physiological and pathological contexts.
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