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Description
PIN1 Recombinant Rabbit mAb (S-2731-43)Product Specification Host Rabbit Antigen PIN1 Synonyms Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis trans isomerase Pin1 (PPIase Pin1); Rotamase Pin1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13526 Clone Number S 2731 43 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, Jurkat, A549, HeLa, NIH 3T3, mouse heart, PC 12, rat brain, COS
Product Specification
| Host | Rabbit |
| Antigen | PIN1 |
| Synonyms | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1); Rotamase Pin1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13526 |
| Clone Number | S-2731-43 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, Jurkat, A549, HeLa, NIH/3T3, mouse heart, PC-12, rat brain, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu |
Background
PIN1 is a conserved 163-residue peptidyl-prolyl cis-trans isomerase composed of an N-terminal WW domain and a C-terminal catalytic PPIase domain, both recognizing pSer/Thr-Pro motifs; by selectively isomerizing these phosphorylated bonds it acts as a post-phosphorylation switch that reshapes the conformation, stability, localization and ubiquitination of hundreds of client proteins—ranging from p53 and cyclins to NF-κB and APP—thereby governing cell-cycle progression, transcription, immune signaling and neuronal homeostasis, while its frequent over-activation in cancer drives oncogenic pathways and its loss contributes to neurodegenerative diseases such as Alzheimer’s.
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