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Description
Keratin 8 Recombinant Rabbit mAb (SDT-016-46)Product Specification Host Rabbit Antigen Keratin 8 Synonyms Cytokeratin 8,Type II keratin Kb8, KRT8,CYK8,CK 8,K8 Immunogen Synthetic Peptide Accession P05787 Clone Number SDT 016 46 Antibody Type Rabbit mAb Isotype IgG2b Application WB, IHC P, ICC, FCM Reactivity Hu Predicted Reactivity Cz Purification Protein A Research Area Signal Transduction Concentration 0. 5mg ml Molecular Weight 53kDa Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Keratin 8 |
| Synonyms | Cytokeratin-8,Type-II keratin Kb8, KRT8,CYK8,CK-8,K8 |
| Immunogen | Synthetic Peptide |
| Accession | P05787 |
| Clone Number | SDT-016-46 |
| Antibody Type | Rabbit mAb |
| Isotype | IgG2b |
| Application | WB, IHC-P, ICC, FCM |
| Reactivity | Hu |
| Predicted Reactivity | Cz |
| Purification | Protein A |
| Research Area | Signal Transduction |
| Concentration | 0.5mg/ml |
| Molecular Weight | 53kDa |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:250 | |
| IHC-P | 1:250-1:1000 | |
| ICFCM | 1:500 |
Background
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in human by the KRT8 gene. In normal tissue, it reacts mainly with secretory epithelia, but not with squamous epithelium, such as that found in the skin, cervix, and esophagus. However, it also reacts with a range of malignant cells, including those derived from secretory epithelia, but also some squamous carcinomata, such as spindle cell carcinoma. It also reacts with neuroendocrine tumors.Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
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