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Description
CD11c IHCstart KitProduct Specification Application IHC P Reactivity Hu Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage Primary antibody: 12 months from date of receipt reconstitution, 20 C as supplied IHC detection kit: 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution species IHC 1: 500 Background CD11c, also known as Integrin, is an integrin alpha X chain
Product Specification
| Application | IHC-P |
| Reactivity | Hu |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | Primary antibody:12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 |
Background
CD11c, also known as Integrin, is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. The reagent can complete 50 slides for IHC experiment and the primary antibody is excessive.
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