SKU: 57523837284

FITC Rat Anti-Mouse FR4 Antibody (S-R705)

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Description

FITC Rat Anti-Mouse FR4 Antibody (S-R705)Product Specification Host Rat Antigen FR4 Synonyms Sperm egg fusion protein Juno; Folate receptor 4; Folate receptor delta (FR delta); Folate binding protein 3; IZUMO1 receptor protein JUNO; Izumo1r; Folbp3; Folr4; Juno Location Cell membrane Accession Q9EQF4 Clone Number S R705 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Purification Protein G Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1%

Product Specification


Host Rat
Antigen FR4
Synonyms Sperm-egg fusion protein Juno; Folate receptor 4; Folate receptor delta (FR-delta); Folate-binding protein 3; IZUMO1 receptor protein JUNO; Izumo1r; Folbp3; Folr4; Juno
Location Cell membrane
Accession Q9EQF4
Clone Number S-R705
Antibody Type Rat mAb
Isotype IgG1,k
Application FCM
Reactivity Ms
Purification Protein G
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5 μl per million cells in 100μl volume

Background

Folate receptor 4 (FR4), also known as folate receptor delta or IZUMO1R, is a protein encoded by the FOLR4 gene in humans. It is a subtype of the receptor for the vitamin folic acid and is primarily expressed on CD4 T lymphocytes, with lower expression on CD8 T cells. FR4 is highly expressed in regulatory T cells (Tregs) and is also found in tumor-associated macrophages (TAMs) and T follicular helper cells (TFH cells). This protein plays a role in immune regulation, as its high expression can distinguish Tregs from other T cells. Additionally, FR4 is involved in the high-affinity binding and transport of folate and folate analogs across the cell membrane.

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SKU: 57523837284

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