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Description
CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532
Product Specification
| Species | Mouse |
| Synonyms | CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein |
| Accession | P05532-2 |
| Amino Acid Sequence | Ser25-Pro523, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 95-120kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
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Background
Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
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4.5 ★★★★★
Based on 756 reviews
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Product Reviews
★★★★★ 5
Outstanding book that lays out a blueprint for communist China's war against the US
A short book that sometimes slips into expressions that take a little time to understand, the two political officers that wrote this book had truly studied US (and western) military campaigns and political movements in order to develop strategies to defeat the west without kinetic warfare.
While I (like most others, I believe) understood that CCP wanted to take advantage of the US and have region dominance, this book really opened my eyes. I'll merely list the areas in which these two political officers promoted engagement against the US/west - actions that many (including myself) never realizing these were acts of "unrestricted" and comprehensive warfare. The list:
diplomatic warfare
financial warfare
conventional warfare
network warfare
trade warfare
bio-chemical warfare
intelligence warfare
resource warfare
ecological warfare
psychological warfare
economic aid warfare
space warfare
tactical warfare
regulatory warfare
electronic warfare
smuggling warfare
sanction warfare
guerrilla warfare
drug warfare
media warfare
terrorist warfare
virtual warfare (deterrence)
ideological warfare
fabrication warfare
cultural warfare
international law warfare
atomic warfare
Of course, as one recognizes these listed arenas of engagement communist China has with the US, remember that espionage and propaganda play key roles in all of these areas. While the US seeks to counter communist China individually in several of these areas, we have to realize that it is a comprehensive strategy that the CCP is pursuing. Remember this book was published in 1999. What has each side engaged in since then?
Epiphanal!
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Reviewed in the United States on December 16, 2022
★★★★★ 3
A military reading: The cover is misleading
This book is purported to be a translation of China’s Masterplan to Destroy America written by two Colonels in the People’s Liberation Army in 1999. There is reason, but not confirmed, to doubt this. The authors of the book are clearly Chinese. Whether or not the authors are Colonels in the PLA, I feel, is in doubt, as such a plan would never be available to Western sources as quickly as it was after drafting.
The book is no “master plan.” It is a discussion of modern warfare strategy written by readers of the worldwide military strategy publications. Most of the publications have been in the United States and China. The cover of this book is misleading with the statement, “Wake up, America.” This book should be little interest to the non-military American. But it should be read by anyone with potential requirements for field grade service (Major and above,) or higher (and equivalent strategy levels in the Marines, Air Force, and Navy.) As far as “Wake Up,” I can recall discussions about strategy that contained most of the information provided within the book as a staff field grade officer in the US Army. While as military officers, we need to be aware of these issues, we are not entirely ignorant of them. The book provides a somewhat different perspective of the issues from a Chinese viewpoint.
The first point the authors make, how technology precedes its best employment in warfare. Most of the technology discussed concerns the information processing capabilities of both computers and software. It is more than computerized warfare. A large part of this is based on the technology to US Forces but not entirely. Part of the problem with technology is that mankind becomes so used to using technology to solve today’s problems that previous methods of solving problems are lost. Thus, if the technology can be crippled, it represents an exploitable weakness in war.
The second point made, is that the military forces now must consider nonmilitary actions if it is to be effective in both defense and offense. Warfare developed from point battlefields (using swords, knives, etc.,) to linear battlefields (using machine guns and artillery,) to area battlefields, to 3D battlefields (using aircraft and missiles,) to modern infinite-dimensional battlefields which include space, electromagnetic spectrums, and civilian actions. If one can start a war in a computer room or a stock exchange, is there a non-battle space anywhere? Warfare that transcends military boundaries is “unrestricted warfare.” A “kinder warfare” with critical attacks that take no lives is now possible. Technology is providing a means to attack and enemy’s nerve centers without directly harming anything else. Such nerve centers exist in an enemy’s financial systems, their economic systems, their environmental systems, their public media systems, their political systems, their power and energy systems, and their logistics centers.
A third point made is that coalitions of disparate forces, internationally, nationally, and military, are formed and broken very quickly, as quickly as within 24 hours! For example, in Desert Storm, the United States weaved together more than 30 nations in various roles. The author’s prescient comment foresaw the alignments that occurred immediately following the 9/11 attack, although this was after the book was written and not available to the authors to use as an example. There was also unity of command established. This, the authors say, stemmed from the US DoD Reorganization Act passed by Congress in 1986. All of the air forces and naval forces were under General Schwartzkopf despite the desires of the individual forces to operate independently. The air tasking order (a 300-page document) drafted in joint sessions by the Air Force, Navy and Marines, had to be approved by General Schwartzkopf before commands were issued to the various forces. The Kuwaiti Invasion Plan that the Marines wanted was put off in favor of the plan that General Schwartzkopf endorsed. Media personnel were incorporated into the military units but controlled with definitions of release timing and content.
A fourth point is that Americans want wars which achieve its national interests while having no causalities. This promotes an over-reliance on technology and an unwillingness to support prolonged war. Americans have a blind faith in technology always thinking that the road to victory is with the highest technology weapons. American military budgets are based largely on the acquisition of expensive weapon systems, and little thought given to their integrated use within the military services. American military theory is behind (consistent with point one above.) But the overriding goal is victory without casualties. Thus, the authors recommend that the secret to war with America is to kill its rank and file soldiers.
The style of the book is somewhat elliptical: it is written in the Chinese manner which often dances around a subject before coming to its subject. For example, there is a discussion of the Golden Ratio (1:0.618) before the authors show how it can be found in various ancient and modern military operations. There is considerable Chinese military philosophy discussed including the 36 Strategies, which most American military readers have not encountered ( did not at West Point when I was a Cadet studying Chinese!) I first encountered these after a reference from a Chinese Professor while I was teaching in China and then read Sun Tzu in Chinese. Sun Tzu was not the original author of these. In my personal opinion, an English translation this short book should be required reading for all Cadets at West Point.
I rate the book 3 stars for several reasons. I don’t feel the book is well written. Many of the references are transliterations of the author’s names in Chinese which do not read as the real names. At this time, the book is somewhat dated having been written in 1999. I also doubt the attribution of the source and authors of the book. The concepts presented in the book are worth thinking about for a person developing military strategies.
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Reviewed in the United States on September 16, 2019
★★★★★ 5
No complaints
Format: Paperback
Knowledge is power and everybody should read this book
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Reviewed in the United States on December 3, 2025
★★★★★ 5
Fascinating and beautifully written.
Format: Hardcover
Clear and compelling reading of the much-neglected history of Carthage -- all its histories had been written by the victors in Rome. BTEW y four-colour photo insert was missing a page....shame on Norton, the puboisher.
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Reviewed in the United States on March 25, 2026
★★★★★ 4
Excellent Overview of Carthage
Format: Hardcover
293 pages of text/maps/b&w figures; 8 pages of color plates; 15 pages of end notes (mostly citations); 20 page Bibliography; 6 page Primary Bibliography; 2 page Acknowledgements; 8 area maps; 1 battle map [Cannae]. This is a well written history of Carthage. It provides a one source overview of the background and history of the city/empire. As a reasonably well read layperson, I am familiar at an overview level with the Punic Wars, Rome, Alexander, and the Alexandrine successor states and this book packaged Carthaginian information very well while adding interesting information that I hadn't come across before. I was somewhat disappointed (hence the 4 star rather than 5 star rating) that there was a very limited drill down to a lower level of detail, particularly from such a noted author. However, this is probably an unfair criticism given the limited amount of archeological information available and the millennia of effort that has been spent in pigeonholing Carthage according to the desired perceptions. I recommend the book highly as a well written overview of Carthage.
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Reviewed in the United States on April 2, 2026
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