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The Memory Thief : And the Secrets Behind How We Remember: A Medical Mystery336 pages Hardcover The remarkable true story of a team of doctors who through years of scientific sleuthing and observant carediscover a surprising connection between opioids and memory, one that holds promise and peril for any one of us. How could you lose your memory overnight, and what would it mean? The day neurologist Jed Barash sees the baffling brain scan of a young patient with devastating amnesia marks the beginning of a quest to answer
336 pages | Hardcover
The remarkable true story of a team of doctors who – through years of scientific sleuthing and observant care—discover a surprising connection between opioids and memory, one that holds promise and peril for any one of us.
How could you lose your memory overnight, and what would it mean? The day neurologist Jed Barash sees the baffling brain scan of a young patient with devastating amnesia marks the beginning of a quest to answer those questions. First detected in a cluster of stigmatized opioid overdose victims in Massachusetts with severe damage to the hippocampus—the brain’s memory center—this rare syndrome reveals how the tragic plight of the unfortunate few can open the door to advances in medical science.
After overcoming initial skepticism that investigating the syndrome is worth the effort—and that fentanyl is the likely culprit—Barash and a growing team of dedicated doctors explore the threat that people who take opioids chronically as prescribed to treat severe pain may gradually put their memories at risk. At the same time, they begin to grasp the potential for this syndrome to shed light on the most elusive memory thief of all—Alzheimer’s disease.
Through the prism of this fascinating story, Aguirre goes on to examine how researchers tease out the fundamental nature of memory and the many mysteries still to be solved. Where do memories live? Why do we forget most of what happens in a day but remember some events with stunning clarity years later? How real are our memories? And what purpose do they actually serve?
Perhaps the greatest mystery in The Memory Thief is why Alzheimer’s has evaded capture for a century even though it afflicts tens of millions around the world and lies in wait for millions more. Aguirre deftly explores this question and reveals promising new strategies and developments that may finally break the long stalemate in the fight against this dreaded disease.
But at its core, Aguirre’s genre-bending and deeply-reported book is about paying attention to the things that initially don’t make sense—like the amnestic syndrome—and how these mysteries can move science closer to an ever-evolving version of the truth.
How could you lose your memory overnight, and what would it mean? The day neurologist Jed Barash sees the baffling brain scan of a young patient with devastating amnesia marks the beginning of a quest to answer those questions. First detected in a cluster of stigmatized opioid overdose victims in Massachusetts with severe damage to the hippocampus—the brain’s memory center—this rare syndrome reveals how the tragic plight of the unfortunate few can open the door to advances in medical science.
After overcoming initial skepticism that investigating the syndrome is worth the effort—and that fentanyl is the likely culprit—Barash and a growing team of dedicated doctors explore the threat that people who take opioids chronically as prescribed to treat severe pain may gradually put their memories at risk. At the same time, they begin to grasp the potential for this syndrome to shed light on the most elusive memory thief of all—Alzheimer’s disease.
Through the prism of this fascinating story, Aguirre goes on to examine how researchers tease out the fundamental nature of memory and the many mysteries still to be solved. Where do memories live? Why do we forget most of what happens in a day but remember some events with stunning clarity years later? How real are our memories? And what purpose do they actually serve?
Perhaps the greatest mystery in The Memory Thief is why Alzheimer’s has evaded capture for a century even though it afflicts tens of millions around the world and lies in wait for millions more. Aguirre deftly explores this question and reveals promising new strategies and developments that may finally break the long stalemate in the fight against this dreaded disease.
But at its core, Aguirre’s genre-bending and deeply-reported book is about paying attention to the things that initially don’t make sense—like the amnestic syndrome—and how these mysteries can move science closer to an ever-evolving version of the truth.
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4.4 ★★★★★
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Product Reviews
★★★★★ 5
Cute shoes for new walkers
Great shoes for new walkers, with a sturdy heel cup and flexible sole, and super easy to get on/take off. The fit is a bit on the narrow side, so recommend checking the size chart. Great colors too! We've bought multiple pairs in different sizes and have always been happy.
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Reviewed in the United States on October 29, 2021
★★★★★ 5
Great shoe: 5th pair purchased!
I love these shoes! They fit true to size and never wear out. Both of my girls have worn these exclusively from 9 months through kindergarten. My oldest just learned to tie laces and that’s the only reason I’m moving her on to different shoes. These are stylish and they grow out of them before the tread even begins to show wear. Additionally, unlike cheap sneakers from Walmart or Target the Velcro holds strong despite a year of use by two different children.
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Reviewed in the United States on May 15, 2019
★★★★★ 5
Great purchase!
My child is 14 months and has been on the move for a long time, these shoes are so great, he moves great in them and never has a problem wearing them!
They are slightly narrow so the strap doesn’t go all the way, but has never come undone!
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Reviewed in the United States on August 10, 2023
★★★★★ 5
Worth every penny
My son’s favorite shoes! High quality, very durable, look nice even when they aren’t freshly cleaned. Easy to take on and off. Definitely worth the money! This color tends to go with everything. Such great support.
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Reviewed in the United States on June 15, 2021
★★★★★ 5
Perfect fit.
Color: Grey/Navy/Green, Size: 3.5 Big Kid
Nice looking shoes, Saucony is always very durable for my child and myself. Very comfortable and fit perfectly. Great for just hanging out or running.
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Reviewed in the United States on August 28, 2025