SKU: 95149078586

Ortho Molecular Methyl CpG Cardiovascular Health 60 capsules

Sale price$44.99 Regular price$49.99
Save 10%

Pay in installments of $12.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 2 - Aug 7

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Ortho Molecular Methyl CpG Cardiovascular Health 60 capsulesMethyl CpG Methyl CpG is a comprehensive formula that includes targeted amounts of five key nutrients designed to support methylation and homocysteine balance in the body. Categories: Cardiovascular Health, Essential Vitamins, Essential Health, Best Sellers Clinical Applications Supports Optimal Methylation and Cardiovascular Health Supports Healthy Homocysteine Levels Increases Neurotransmitter Production Supports Primary Detoxification Pathways

Methyl CpG®

Methyl CpG® is a comprehensive formula that includes targeted amounts of five key nutrients designed to support methylation and homocysteine balance in the body.

Categories:

Cardiovascular Health, Essential Vitamins, Essential Health, Best Sellers

Clinical Applications
  • Supports Optimal Methylation and Cardiovascular Health
  • Supports Healthy Homocysteine Levels
  • Increases Neurotransmitter Production
  • Supports Primary Detoxification Pathways
  • Promotes DNA Repair

Methylation is a vitamin-requiring biochemical process in the body that is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins.

Methyl CpG® provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. The formula includes key methylation vitamins B2, B6 and B12 (methylcobalamin). This specific blend of methyl donors promotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification.

Suggested Use:

1 capsule per day or as recommended by your health care professional.

 Benefits 

Folate

Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is abundantly found in foods such as fruits and dark leafy vegetables but, can be easily destroyed by cooking or processing. The bioactive form of folate is 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is required as a methyl group donor for several processes, including the production of mood regulating neurotransmitters, the synthesis of melatonin, and DNA production and repair.

Vitamin B12

Vitamin B12 works with folate in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly run the highest risk of B12 deficiency. Methylcobalamin is the preferred form of B12 as it is the biologically active form of B12 and supports the up-regulation of methylation pathways.

Vitamin B6

Vitamin B6 is a crucial B vitamin that is involved in the production of proteins in the body, neurotransmitters that help regulate mood, red blood cell formation and the proper functioning of the immune system. B6 is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with 5-MTHF and B12 in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining normal blood pressure.

Vitamin B2

Optimizing B2 (riboflavin) status helps support healthy blood pressure. Supporting riboflavin status also appears to stabilize MTHFR, the enzyme required for 5-MTHF which converts homocysteine to methionine.

Trimethylglycine (Betaine)

As a methyl donor, trimethylglycine supports liver function, including detoxification pathways. Trimethylglycine has been shown to protect against chemical damage to the liver. It has also been shown to be beneficial in protecting against fat accumulation in the liver, due to its lipotropic properties. Trimethylglycine also works alongside B2, B6, B12 and folate in maintaining normal homocysteine levels.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 95149078586

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 19 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
B
Verified Purchase
Blackqueen30
Draper, US
★★★★★ 5
Good purchase
Size: 9.5, Color: Black
Value and quality was good
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2026
A
Verified Purchase
Amazon_Customer
Los Angeles, US
★★★★★ 5
The "Lazy Professional" Look: Is Hands-Free Luxury Actually Real?
Size: 9.5, Color: Black Napa Leather
Living down here in Florida, my footwear needs are pretty specific. It’s hot, it’s humid, and I spent half my life rushing from the car into work or a meeting. I’ve reached that age where I value efficiency just as much as style—maybe more. I’ve been eyeing the Marc Joseph New York Hands-Free Slip-on Penny Loafers for a while, and after putting them through the wringer, here is the honest truth from someone who just wants to look sharp without the hassle. The "Just Step-In" Reality Look, the big selling point here is the "Hands-Free" tech. We’ve all seen the commercials for those athletic slip-ins, but finding that in a legitimate leather penny loafer is a different game. Does it work? Yes, surprisingly well. The heel counter is firm enough that it doesn’t collapse when you slide your foot in, but it doesn’t feel like a piece of plastic digging into your Achilles once you’re in. For those of us who are tired of bending over or hunting for a shoehorn every morning, this is a genuine quality-of-life upgrade. The Florida Factor: Comfort and Style The leather is actual calfskin (on most models), which is a must for the Florida heat. Synthetic shoes turn into a sauna within ten minutes, but these breathe reasonably well. The aesthetic is classic—it’s a "professor" shoe through and through. You can wear them with chinos and a blazer for work or throw them on with some nice jeans for a weekend lunch. Inside, they’ve got a gel heel insert and a padded footbed. It’s not quite "walking on a cloud"—let’s not over-hype it—but it’s a massive step up from the hard, flat soles of traditional dress loafers. I’ve spent four hours on my feet lecturing, and my arches didn’t hate me by the end of the day. The Sizing Gamble Here’s where you need to be careful. The consensus from other guys (and my own experience) is that the sizing is a bit of a coin toss. They tend to run a little large and sometimes wide. If you have narrow feet, you might find the sides "gaping" or flaring out when you walk, which kills the sleek look. I’d recommend ordering a half-size down if you’re usually between sizes. The Breakdown The Pros: True Hands-Free: You can actually put these on while holding a coffee and a briefcase. No hands needed. Legit Materials: The calf leather feels premium and smells like the real deal. Versatility: Perfectly bridges the gap between a "car shoe" and a formal loafer. Comfort: The gel insert makes a noticeable difference for long-duration wear. The Cons: Sizing Inconsistency: They can run wide, leading to some "heel slip" if you don't get the perfect fit. Break-in Period: The heel is stiff by design (to allow for the slip-on feature), so expect a day or two of minor stiffness. Price Point: They aren't cheap, though often on sale. Value for Money Are they worth it? If you’re comparing them to high-end Italian brands that cost $500, these are an absolute steal. They look 90% as good for a fraction of the price. However, if you're used to $60 mall shoes, the jump to $150+ might feel steep until you realize you’re paying for the convenience of never having to touch your shoes to put them on. For a daily driver in a professional setting, the value is definitely there.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2026
E
Verified Purchase
Edward A. Cleveland
Belleville, US
★★★★★ 5
Step In Look Good
Size: 11.5, Color: Cognac Napa Leather
I am wearing these shoes as I write this review, and they look and feel great. I have a bit of a disability with drop foot on the right leg and bilateral neuropathy and have been wearing step in shoes for about 10 years. But the first company that introduced leather dress and casual shoes stopped making them and now only makes sport and casual shoes. So I have been searching for some that meet my need for shoes like this and this company has given me three pairs, so far. Easy to get into, comfortable to wear, and good looking. And they take polish very well, too. (Remember how to do that?). We may buy another pair or two in different styles as well.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
B
Verified Purchase
Book dude
New York, US
★★★★★ 4
Runs tight. Skinny and smaller than other brands.
Size: 8.5, Color: Brown
Comfy and lots of support. Cushiony. Beware: the brown I ordered runs small. Tighter than other brands.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2026
L
Verified Purchase
Loren
Lowell, US
★★★★★ 5
Right Decision
Size: 12 Wide, Color: Cognac Napa Leather
Very comfortable. Classic style.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026

recommand products