SKU: 38308605617

PRIME TIME+ (AUTOPHAGY) - 90 Capsules *

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Description

PRIME TIME+ (AUTOPHAGY) - 90 Capsules *Prime Time+ is a cutting edge formula designed to support healthy aging by optimizing the bodys natural renewal processes. Powered by an industry leading 10mg's of spermidine per serving, Prime Time+ helps activate autophagy, the bodys mechanism for clearing out old, damaged cells, while promoting the rejuvenation of stem cells. By mimicking the effects of fasting, this comprehensive blend encourages cellular regeneration and the efficient removal of

Prime Time+ is a cutting-edge formula designed to support healthy aging by optimizing the body’s natural renewal processes. Powered by an industry-leading 10mg's of spermidine per serving, Prime Time+ helps activate autophagy, the body’s mechanism for clearing out old, damaged cells, while promoting the rejuvenation of stem cells. By mimicking the effects of fasting, this comprehensive blend encourages cellular regeneration and the efficient removal of aged cells, enhancing overall healthspan.

In addition to its role in autophagy, Prime Time+ supports stem cell release and migration, crucial for tissue repair and cellular renewal. These stem cells play a vital role in maintaining organ and tissue health, promoting recovery, and enhancing vitality. Backed by emerging research, Prime Time+ is an essential part of any longevity protocol, empowering you to optimize vitality, cellular health, and the body’s natural healing processes.

Prime Time+ was formulated to support:  

  • Stem cell release and migration*
  • Boosting autophagy and promote cellular renewal* 
  • Fasting*
  • Helps to preserve, protect, and regenerate the endothelial glycocalyx*
  • The body’s innate repair system*
  • Strengthens and enhance the body’s natural immune response*
  • Epigenetic aging support* 
  • Modulates natural inflammatory responses*
  • Skin and eye health*

Spermidine
Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan. 

The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms. 

Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways.

CyanthOx™ Sea Buckthorn Extract

CyanthOx™ is a potent extract derived from the ancient Sea Buckthorn plant, native to the Tibetan Plateau, which has evolved over a billion years to develop a unique blend of polyphenols, proanthocyanidins, and flavonoids. This powerful combination of antioxidants gives CyanthOx™ exceptional free radical-scavenging properties, contributing to a wide array of health benefits. Recent clinical research published in Clinical Interventions in Aging highlights its ability to stimulate three distinct types of stem cells, supporting anti-aging, reducing inflammation, and promoting skin vitality, vascular health, and improved blood circulation. CyanthOx™ harnesses the power of nature’s evolutionary defense mechanisms to deliver unparalleled support for overall health and longevity.

StemEnhance® (Aphanizomenon flos-aquae concentrate(AFA)

Aphanizomenon flos-aquae (AFA) concentrate is a rare, nutrient-rich blue-green algae harvested from the pristine waters of Upper Klamath Lake in Oregon, enhanced with a concentrated dose of AFA polysaccharides. What sets AFA apart is its exceptional nutrient profile, providing bioavailable essential amino acids, vitamins, minerals, and powerful antioxidants. Notably, it boasts a high concentration of phycocyanin, a potent antioxidant with strong anti-inflammatory and immune-enhancing effects. Phycocyanin is also known for stimulating the production and release of adult stem cells, which play a key role in cellular repair and regeneration.

Additionally, AFA contains phenylethylamine (PEA), often referred to as the "molecule of love," which helps elevate mood, enhance mental clarity, and improve cognitive function. This unique blend of nutrients positions AFA as a true brain and body health booster, supporting energy levels, immune function, cellular renewal, and overall vitality. AFA’s primary mechanism of action involves inhibiting the production of the inflammatory eicosanoid leukotriene B4, further promoting a balanced immune response. StemEnhance® supports the increase of immune function by stimulating the release of stem cells from the bone marrow. 

CyaninPlus® Blue Spirulina Extract (Phycocyanin >30%)

CyaninPlus® Blue Spirulina Extract, standardized to contain more than 30% phycocyanin, offers a powerful array of health benefits thanks to its rich antioxidant and anti-inflammatory properties. Phycocyanin, the active compound in Blue Spirulina, helps neutralize harmful free radicals, protecting cells from oxidative stress and reducing inflammation throughout the body mainly due to it being one of the strongest natural COX-2 inhibitors. This potent extract supports a healthy immune system, promotes detoxification, and has been shown to enhance liver function and overall energy levels. Additionally, CyaninPlus® is a nutrient-dense source of essential amino acids, vitamins, and minerals, contributing to improved vitality, cellular health, and longevity. 

Fucoidan from Mekabu (Undaria pinnatifida) (sporophyll)

Mekabu Extract, derived from the sporophyll of Undaria pinnatifida (a type of brown seaweed), is rich in fucoidan, a bioactive compound with extensive health benefits. Standardized to contain 85% fucoidan, Mekabu Extract is renowned for its immune-boosting, anti-inflammatory, and antioxidant properties. Fucoidan has been shown to support healthy cell regeneration, promote immune function, and enhance the body’s natural ability to fend off pathogens. Additionally, it aids in protecting against oxidative stress, helping to maintain cellular integrity and overall vitality. Research also suggests that fucoidan can be a autophagy regulator and is a known stem cell mobilizer. 

Astaxanthin (Haematococcus pluvialis microalgae extract) (as AstaReal®)

AstaReal® Astaxanthin is the most studied brand of astaxanthin in the world for applications such as skin health, anti-aging, muscle endurance and recovery, and eye health. Astaxanthin is a powerful carotenoid and antioxidant that plays a crucial role in promoting autophagy, supporting stem cell health, and enhancing healthspan. As a potent antioxidant, astaxanthin helps protect cells from oxidative stress, which can hinder cellular function and accelerate aging. By reducing oxidative damage, astaxanthin encourages the body’s natural autophagy processes, allowing for the removal of damaged proteins and organelles, and promoting the regeneration of healthier cells. This is particularly important for maintaining the vitality of stem cells, which are essential for tissue repair and regeneration. Furthermore, astaxanthin has been shown to modulate key signaling pathways involved in cellular health, enhancing mitochondrial function and promoting metabolic efficiency. By fostering a healthy environment for stem cells and enhancing autophagy, astaxanthin contributes significantly to improved overall health, longevity, and resilience against age-related diseases.

Pure Mune organic yeast beta 1,3 /1,6 glucan

PureMune™ organic yeast beta 1,3/1,6 glucan is a vital nutritional supplement known for its powerful immune-modulating properties which helps facilitate autophagy. Derived from the cell walls of yeast, this natural polysaccharide acts as a potent immune enhancer, stimulating the body’s immune system to respond more effectively to pathogens. Beta glucans have been shown to activate key immune cells, such as macrophages and natural killer (NK) cells, enhancing their ability to recognize and eliminate harmful invaders. Additionally, PureMune™ supports overall immune health by promoting a balanced inflammatory response and reducing the risk of infections.

Green Tea providing Epigallocatechin-3-gallate (EGCG)

Epigallocatechin-3-gallate (EGCG), the most potent catechin in green tea, has emerged as a key compound in the realm of anti-aging and cellular rejuvenation. Its broad range of health benefits is particularly relevant for supporting stem cells and promoting autophagy—two fundamental processes linked to longevity and vitality.

One of EGCG’s primary mechanisms involves its robust antioxidant activity. By neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS), EGCG helps reduce oxidative stress, a major driver of cellular damage and senescence. This action protects cells from premature aging and promotes their ability to regenerate, making EGCG a valuable ally in maintaining stem cell health and function. Additionally, EGCG has been shown to stimulate autophagy, the body’s natural process of removing damaged cells and recycling cellular components

Alpha-ketoglutarate (AKG)

Alpha-ketoglutarate (AKG) is a vital molecule that plays a key role in numerous metabolic and cellular functions, but its levels naturally decline as we age. AKG serves as a critical energy donor, supports the production of amino acids, and functions as a powerful cellular signaling molecule. Additionally, it regulates epigenetic processes that influence gene expression, making it essential for maintaining cellular health and metabolic balance. As a multifaceted compound, AKG helps optimize energy production, cellular regeneration, and overall metabolic function, making it an important nutrient for healthy aging and longevity.

Apigenin

Apigenin is a powerful natural bioactive plant polyphenol known for its antioxidant, anti-inflammatory, and immune-boosting properties. It plays a crucial role in protecting cells from oxidative stress, which helps improve overall cellular function and resilience. By neutralizing harmful free radicals and reducing inflammation, apigenin supports healthier aging, enhances the body’s defense mechanisms, and promotes optimal cellular performance, contributing to long-term well-being and vitalityStudies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels.

Luteolin

Luteolin is a naturally occurring flavonoid found in a variety of plants, known for its significant health-promoting properties. As a potent antioxidant, luteolin helps to combat oxidative stress, which plays a key role in cellular aging and disease development. By neutralizing free radicals, luteolin supports overall cellular health and contributes to the protection of tissues and organs, making it a valuable compound for promoting long-term wellness and resilience.

AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1

AstraGin®, a proprietary blend of root extracts from Astragalus membranaceus and Panax notoginseng, plays a significant role in supporting stem cell health and enhancing autophagy. The key bioactive compounds, astragaloside I, IV, and ginsenoside Rb1, are known to promote cellular regeneration and repair by increasing the activity of stem cells. Astragalosides, particularly astragaloside IV, have been shown to stimulate the proliferation of stem cells, aiding in tissue regeneration and supporting the body's natural healing processes. Ginsenoside Rb1, on the other hand, helps enhance autophagy, the process by which cells remove damaged components and recycle them for cellular maintenance. Together, these compounds work synergistically to boost stem cell activity, improve cellular health, and support the body's natural autophagy mechanisms, which are crucial for longevity and healthy aging.

Ioniplex® (Fulvic Ionic Mineral Complex)

Ioniplex® is a natural fulvic ionic mineral complex designed to enhance nutrient absorption and cellular energy production. By facilitating the transport of essential nutrients into cells while aiding in the removal of waste, it supports the body’s natural detoxification processes. Clinically tested, Ioniplex® has been shown to improve mitochondrial function, optimize glucose metabolism, and promote effective detoxification, making it a powerful component for overall health and vitality.

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SKU: 38308605617

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4.1 ★★★★★
Based on 1215 reviews
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Product Reviews
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Betty Jo Bradley
Alexandria, US
★★★★★ 4
Great alternative to the grunting pigs!
Color: Pink, Style: Grunt Sound
We go through A LOT of dog toys at my dog based business. The grunting pigs are super cute, but they are also super fragile. It is incredibly easy to dislodge the squeaker. (Grunter?) These are certainly not robust chew toys, but the squeaker is about 30% better at staying put than that of the pigs. It's also smaller, so it's easier for the smaller dogs to play with. These are a new favorite! Update: August, 2024 I bought an orange hedgehog. Amazon won't let me review that separately so I had to add to my sheep review. The orange hedgehog is only 3 stars. It is made of a harder plastic than the bear and the sheep. It also has a standard squeaker, not the grunting of the bear and sheep. But harder plastic DOES NOT mean that it will withstand an aggressive chewer! If your dog likes to "kill the squeaker" they will be able to do so in minutes! This IS NOT a chew toy! If you are looking for a toy for an aggressive chewer, look at the Orbeez line from Outward Hound. The other thing that makes me less enthusiastic about the orange hedgehog is that the yellow paint started flaking off immediately. I will have to scrub it all off because it looks terrible! The dogs don't care, but their owners sure do! I haven't had that problem with the sheep or the bears. The orange hedgehog is almost like it's from a completely different company!
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Reviewed in the United States on February 16, 2024
M
Verified Purchase
Maeberry
Cuba, US
★★★★★ 3
Cute
Color: Pink, Style: Grunt Sound
Really cute toy broke in a day and It stopped honking but my dog still plays with it. Durable material. Good toy overall. Please fix the honk and we can buy more like it.
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Reviewed in the United States on April 1, 2026
F
Verified Purchase
FL Sunshine
Port Orchard, US
★★★★★ 5
Great find for my dog!
Color: Hedgehog, Style: Big Squeak Hedgehog
This is a Big squeaking toy And has become a favorite of my dog. He is a big chewer but he won’t chew at this one he just carries it around and plays catch with it. I believe the little spikes keeps him from heavy chewing on it! Great find for us! But it is a loud squeak!
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Reviewed in the United States on March 26, 2026
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Verified Purchase
nonigrams
Louisville, US
★★★★★ 5
For the love of a dog!
Color: Blue, Style: Tootiez Hedgehog, Color: Blue, Style: Tootiez Hedgehog
Okay, first - this toy is a hoot. When you first get it and hear it's cute grunting/tooting sound, you can't help but grin and think, Yup! That sounds like somebody in here just tooted! Which for some reason always does seem to be a bit funny, doesn't it? And you'll probably find yourself chuckling a little and saying, Oh how cute. After that, the next logical step is you'll introduce the toy to your dog. And then, depending on your dog's particular personality, you may soon discover (as we did) the amazing love/hate relationship a human can develop with a simple dog toy. We have a 1-yr-old standard poodle whom we named Kenda. And yes, he is named after Joe (for any of you ID fans out there). His official AKC registered name is Lieutenant Kenda, Home Inside Hunter. Corny? No doubt. But it truly seemed an appropriate name for him, because this is the first dog we've ever owned that actually LOVES to play with dog toys and will endlessly hunt them down throughout the house. No toy, however well hidden, stands a chance with this determined toy hunter. As Joe might say, he WILL find you! :) His toys are his friends, and he is fiercely devoted to them. Enter the adorable little rubber hedgehog with his even more adorable "toot". The moment Kenda laid eyes (or ears?) on this little guy, all other toys were forgotten. It was love at first sight. So much so that within a few hours of him playing with this toy to the exclusion of all others, we decided to give him a name. We call him "Blue" (I know, we're so creative). Blue immediately became Kenda's best friend - or at least his best toy. He played with him constantly. He bit him, he wrestled with him, he chewed on him. He brought Blue to us and, if we were sitting down, very carefully placed this slobbery ball of rubber in our laps, as if asking, Can we play catch with Blue? Huh? Pretty please?? Sometimes we did, sometimes we didn't. On those occasions when we didn't, he would play catch with himself, picking Blue up in his mouth, swinging his head, and tossing him across the kitchen; then running/sliding across the kitchen floor to retrieve him on the other side of the room. In the beginning, if Blue was nowhere in sight (and with dogs, out of sight is usually out of mind), the hubby and I would get a kick out of saying, "Kenda, where's Blue?!" Just for the enormous fun of watching a 55-pound poodle suddenly leap a foot in the air, scramble his legs mid-air like Fred Flintstone getting his car started, then half running/half sliding across the kitchen hardwood floor in a desperate effort to find his beloved Blue. Oh, how we entertained ourselves in those early days watching Kenda with his Blue. And through it all, through every bite, squeeze, toss, push, throw, and chew of this toy.......the toot. The grunt. Okay, let's call it what it really sounds like, folks: a FART, okay? There, I've said it. It sounds like your grandpa just passed gas - bigtime. Funny? At first, yes. Hilarious. But a thousand times a day? Over and over and over? While you're trying to talk on the phone? While you're trying to have conversation with each other over coffee at the end of the day? Sometimes for an hour NON-STOP? Well, let's just say the humor of it all began to elude us a bit. And therein lies our love/hate relationship with this adorable little toy. We thought we'd died and gone to heaven one day when Blue stopped tooting. Turns out Kenda had chewed on him so much his tooter (located rather anatomically correctly in his tushie) had fallen out. Or rather IN, since it was now in Blue's tummy. Poor Blue, he couldn't make noise anymore, and although Kenda kept playing with him you could tell he was confused as to why his little buddy had fallen silent and wouldn't "talk" to him anymore. And as much as the hubby and I were enjoying the tooting reprieve, we couldn't take it. By the third silent day, I could almost feel the invisible hands of Amazon coaxing me toward my computer, gently urging me to buy another Blue. But I resisted, folks. I did NOT buy another Blue. I bought TWO more Blues! One for now, and one for that possible future day when this Blue, too, falls silent. Why? Because ... well, because it's BLUE! He's practically a member of the family now. The dog loves Blue, and we love the dog. I guess it's that simple. My final word on this dog toy? It's adorable. It's well made and will hold up to a ton of play and chewing. His tooter may not survive as long; I guess that remains to be seen. And if your dog is anything like mine, well then your sanity may take a hit as well. But if your dog loves his little hedgehog buddy as ours does, and if you love your dog (and you know you do!), then you might decide your sanity is worth the risk. Two thumbs way, WAY up! P.S. Blue now has a friend. We just bought the pink sheep. Kenda is in 7th heaven. Our house sounds like a retirement home after a chili bean supper. And yes, we named him "Pink". I told you - we are nothing if not creative.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2018
S
Verified Purchase
Stacy
Waukegan, US
★★★★★ 5
My Dog's All-Time Favorite Toy
Color: Pink, Style: Grunt Sound
The first one of these I ever got her was at Petco on sale for $1 - best $1 ever! The reviews are right, though. The toy doesn't last forever and it's not good for aggressive chewers. In my opinion, however, that doesn't make it a bad toy. Here's why: Aggressive chewers comments: Getting my sister's French Bulldog a stuffed toy (that's shredded in 5 minutes), compared to my Pitbull who does not tear up any toys, but is a stronger chewer when it comes to bones. My pup does not tear this up at all, but my sister's dog would. My point is: Don't get your dog a soft toy if your dog ruins soft toys. Regarding the not long-lasting comments: the honking noise mechanism inside eventually pops inside the hole, rendering it honkless. Ours lasted about 6 months. It's pretty much impossible to fix unless you want to trouble yourself to fix it for 1 good honk each fix. I would, but I do also have a job to get to. My dog does still carry it around in it's noiseless state, but she doesn't play with it with the same enthusiasm. How did I resolve this? I bought her 5 😂 She's only on her second, but I decided to stock it because they were on sale for $5.10 - I don't think I will get rid of any of them. I will just let her play with them on rotation until they fall apart. Besides all that, my dog just simply loves this toy. I have never seen her so happy & playful with a toy. I can't promise this for your dog, as I can only tell you about mine. We even have a "Sheepy" song. [I have not been paid or given free Sheeps - my Sweet Pea just really loves her Sheepy]
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 26, 2024

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