SKU: 57825988339

Sirtuin 6 Activator - 60 capsules

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Description

Sirtuin 6 Activator - 60 capsulesSirtuin 6 Activator: Inspired by the Blue Zones Activates sirtuin 6 (SIRT6)1,4,6,7* Provides Blue Zone bioactives*5,6 Supports multiple longevity pathways*5 Neutralizes free radicals*5,12 Supports a healthy immune system & inflammatory response* 8,5,9 11 View Certificate of Analysis Not all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic Fucus vesiculosusa special type of seaweed

Sirtuin 6 Activator: Inspired by the Blue Zones

  • Activates sirtuin 6 (SIRT6)1,4,6,7*
  • Provides “Blue Zone” bioactives*5,6
  • Supports multiple longevity pathways*5
  • Neutralizes free radicals*5,12
  • Supports a healthy immune system & inflammatory response* 8,5,9-11

View Certificate of Analysis

Not all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic Fucus vesiculosus—a special type of seaweed renowned for its powerful fucoidan content and abundant marine polyphenols. This premium seaweed extract sets a new benchmark in longevity science.* 2,5,8,13,21,22,25

What Makes Ours Better?

  • Fucoidan-Rich Seaweed: We deliver pure, concentrated seaweed—not synthetic compounds or low-quality extracts—packed with fucoidan, a potent SIRT6 activator.*21,22
  • Longevity Boost: Each serving provides a full 400mg dose of fucoidan, the scientifically-backed compound for healthy aging.*
  • Full Spectrum Support: Our formula blends whole-plant seaweed powder with high-potency extracts, offering a more complete range of bioactive compounds to amplify fucoidan’s anti-aging potential.*12,15
  • Maximized Bioactivity: Unlike many seaweed extracts that lose potency through harsh processing, our fucoidan is gently extracted using a specialized water-based method, preserving its full molecular structure for optimal effectiveness.*5

Why Choose ProHealth?

  • Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
  • Triple Lab Tested: Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.
  • Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
  • Manufactured in the USA: Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.
  • 100-Day Risk-Free Guarantee: We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.

Not all fucoidan is created equal.

For centuries, Japan—home to one of the world’s longest-living populations—has relied on seaweed as a dietary staple, prized for its powerful antioxidants and cellular-protective compounds. Research consistently links regular seaweed consumption to enhanced health and longevity, reinforcing its vital role in healthy aging.*15

Building on this tradition, Sirtuin 6 Activator delivers fucoidan, one of seaweed’s most potent bioactive compounds. Naturally found in the cell walls of brown seaweed, fucoidan is clinically recognized for its ability to activate SIRT6, a key enzyme that supports healthy aging at the cellular level.*1


By activating SIRT6, this fucoidan-rich formula goes beyond simple antioxidant support to revitalize cellular health at its core. Research shows that increased SIRT6 activity can aid in DNA repair, boost genomic stability, and support a healthy systemic inflammatory response—processes linked to longevity in Blue Zone populations.*5,8,9,12,14,16

Emerging studies further suggest that higher SIRT6 activity correlates with longer lifespans in multiple animal species. Scientists are now exploring its potential for brain aging, heart health, and overall longevity, with human trials underway to further uncover its impact on healthy aging.*20,26-28


Sirtuin 6 Activator: Inspired by the Blue Zones

Aging is associated with cellular changes, including DNA damage, inflammation, and metabolic shifts, all of which have been studied in relation to SIRT6’s biological functions. Research suggests that SIRT6 plays a role in key cellular processes that support overall health.*

  • Supports DNA Repair – SIRT6 stabilizes the genome by repairing double-strand breaks and maintaining telomere integrity, reducing genetic instability, a major hallmark of aging.*6
  • Influences Metabolic Balance – SIRT6 shifts cells away from inefficient sugar metabolism and toward fat oxidation, mimicking the anti-aging effects of caloric restriction.*17
  • Clears Senescent Cells – Fucoidan acts as a potential senolytic, helping the body remove dysfunctional cells that drive aging.*4,13,19
  • Protects Mitochondria – SIRT6 supports healthy cellular energy production, safeguarding from oxidative stress so cells can generate energy efficiently.*5

Neutralizes Free Radicals*

Oxidative stress occurs when free radicals accumulate and damage cells, proteins, and DNA—a primary driver of aging. ProHealth Sirtuin 6 Activator combats oxidative damage through multiple pathways:

  • Directly Scavenges Free Radicals – Fucoidan’s unique sulfated polysaccharide structure binds to and neutralizes reactive oxygen species (ROS) before they can harm cells.*12
  • Provides Antioxidant Support – This formula combines fucoidan with polyphloroglucinols, marine polyphenols that strengthen cellular defenses against oxidative damage.*5
  • Enhances Cellular Antioxidant Pathways – By enhancing glutathione and superoxide dismutase (SOD) levels, SIRT6 supports the body’s natural ability to maintain oxidative homeostasis.*12

Supports a Healthy Immune System & Inflammatory Response*

Healthy immune system and inflammatory responses are essential for long-term health and longevity. Research suggests that fucoidan and SIRT6 may help support immune function and inflammation balance through multiple pathways:

  • Supports Immune Cell Activity – Fucoidan supports the activity of macrophages, natural killer (NK) cells, and lymphocytes, helping to maintain a robust immune system and clear damaged cells.*5,8,10
  • Helps Maintain a Healthy Inflammatory Response – SIRT6 influences cytokine activity and inflammatory response mechanisms, helping to support healthy inflammation for optimal aging.* 5,8,9
  • Enhances Gut-Immune Function – Fucoidan supports a healthy gut microbiome, which is closely linked to immune and inflammatory balance.*11

Order now and join the 200,000+ people who trust ProHealth Sirtuin 6 Activator for their cellular health!

Ingredients:

  • Brown Seaweed (Fucus vesiculosus): A rich source of fucoidan, a bioactive polysaccharide recognized for supporting cellular health and activating SIRT6, the longevity enzyme.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

  1. Rahnasto-Rilla M et al. Mar Drugs. 2017;15(6):190.
  2. Kawaguchi T et al. Int J Oncol. 2015;46(5):2216-2222.
  3. Yu W et al. Mol Nutr Food Res. 2017;61(10):1700136.
  4. Cao L et al. Mar Drugs. 2020;18(11):564.
  5. Li B et al. Molecules. 2008;13(8):1671-1695.
  6. López-Otín C et al. Cell. 2023;186(2):243-278.
  7. Iso H and Kubota Y. Asian Pac J Cancer Prev. 2007;8 Suppl:35-80.
  8. Jayawardena TU et al. Mar Drugs. 2022;20(12):755.
  9. Apostolova E et al. Polymers. 2020;12(10):2338.
  10. Bogolitsyn K et al. Plant Foods Hum Nutr. 2024;79(2):511-517.
  11. Luthuli S et al. Mar Drugs. 2019;17(9):487.
  12. Catarino MD et al. Mar Drugs. 2018;16(8):249.
  13. Zhang L et al. Innov Aging. 2022;6(Suppl 1):130.
  14. Myers S et al. Biol Targets Ther. 2011;45.
  15. Myers S. Biol Targets Ther. 2010;33.
  16. Li X et al. Front Cell Dev Biol. 2021;9:641315.
  17. Zhang N et al. Cell Cycle. 2016;15(7):1009-1018.
  18. Chilton WL et al. PLoS ONE. 2014;9(4):e92088.
  19. Akter R et al. Int J Mol Sci. 2021;22(8):4180.
  20. Zhang L et al. Innov Aging. 2022;6(Suppl 1):130.
  21. Gorbunova V. Innov Aging. 2019;3(Suppl 1):S8.
  22. Kawamura A et al. Mar Drugs. 2021;19(8):452.
  23. Willcox DC et al. Ann NY Acad Sci. 2009;1173:126-138.
  24. Buettner D. Natl Geogr Books. 2015.
  25. Korotkov A et al. Trends Cell Biol. 2021;31(12):994-1006.
  26. Zhang L et al. Oxid Med Cell Longev. 2019;2019:8918914.
  27. Yang J et al. Int J Biol Macromol. 2024;277(Pt 3):134397.
  28. Wang K et al. Ther Adv Chronic Dis. 2022;13:20406223221076891.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Fucoidan (from Bladderwrack [Fucus vesiculosus] Whole Plant Extract and Brown Seaweed [Undaria pinnatifida] Whole Plant Extract) 400 mg
Bladderwrack (Fucus vesiculosus) Whole Plant Powder 100 mg
† Daily Value (DV) not established
REV.10.24

  • OTHER INGREDIENTS: Vegetable cellulose (capsule), microcrystalline cellulose, bamboo silica.
    • May contain traces of fish and/or shellfish residue.
  • SUGGESTED DAILY USE: Take one (1) capsule daily, or as directed by your healthcare professional.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 57825988339

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4.4 ★★★★★
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Mesully01
Lake Worth, US
★★★★★ 5
My dogs love fetching this toy, then fighting over who’s going to bring it back to me
Both of my miniature dachshunds took to this tug of war toy immediately after opening it. I liked the fact it didn’t smell terrible like most of the scented dog toys I’ve purchased in the past. Instead this one actually smells good, it’s sweet and fruity smelling. It’s extremely durable and very heavy duty. The only problem is that it’s pretty thick and heavy, especially for my small dogs. They still like playing fetch with it, then fighting over which one gets to bring it back to me. It really would have been the perfect fetching toy for them, if only it had been a little bit smaller and lighter. If you have larger sized dogs who enjoy playing fetch and tug a war, I’d recommend giving it a try.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
T
Toasty
Boise, US
★★★★★ 2
Good Quality Toy, but Not a Hit with My Dogs
I am a bit unsure about this toy. Unfortunately, my dogs do not seem to enjoy it very much. I thought the blueberry apple scent would make it more appealing, but they tend to lose interest almost as quickly as they start playing with it. I was hoping this would be something we could use for games like tug of war, but it just has not held their attention. That said, I may just have picky dogs, so this could be a different experience for others. The reason I gave it two stars instead of one is because the quality is actually quite nice. It feels well made and has a good overall design. However, I would be a little cautious giving it to aggressive chewers, as it seems a bit on the softer side. For dogs that are more gentle with their toys, it would likely be a better fit. The size is also great, and it has a lot of potential. It just has not gotten much use in our house, likely due to my dogs not being fans of the flavor. Overall, if you have picky pups like mine, this may not be the best choice. But for less selective or gentler dogs, it could still be a solid option
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 4, 2026
J
Jay
Phoenix, US
★★★★★ 3
Stretchy, but Smaller & Softer Than Expected; Berry Fragrance Dominates; May be Best 4 Puppies
I was directed to read guidelines that were on the internet, prior to use. I was not expecting that and that was a big turn-off. Basically, it's all about liability, this product has the possibility of being torn apart and I am basically warned that if a piece is chewed off, that's bigger than a grain of rice, to toss, this. I was repeatedly reminded, again and again, and again that pet safety was my responsibility. Yeah, I know that. All these suggestions and warnings should have been made clearer in the listing. Is this built to flex? Yes. Does it bend? Yes. Does it stretch? Yes. Is this rugged? That's open to debate, based on the users, for a puppy, to some degree, but their teeth are very sharp. Is this soft on teeth? I don't disagree. Does this have a durable design? Depends on the user. Floats in water? I do not doubt it. Does this have an enticing scent? For a human, yes, for a pet? Depends if your pet loves berries. This is no pigs ear/bone, so, chewing is not a natural draw that I saw, which I think may be better, because this is soft and easier to tear to pieces than expected. To motivate the first time, I found it best to initiate the tug of war, but this is smaller than I envisioned too, causing me to have to bend considerably to participate. A tennis ball in a tube sock is longer. A two-dog tug of war works best with this. Nevertheless, it's a better toy than teaching pooch to have a battle using clothing, avoiding future attractions to my socks. There is some flexibility to this. Durability is an issue. I think this would have been more interesting if it had been made out of rawhide. It does have a comfortable grip, for a human, but the toy pays a price for that with what I would consider fragility. The berry fragrance dominates, it's nice for a human, but sorry, it ain't no bacon aroma. It's like a thick heavy rubber hose. Value? In hindsight, I just do not see the value I was expecting. I mean really, a grain of rice warning not to use. Durability at issue in my eyes. Country of origin? Vietnam. Is this perfect? Not in my opinion. Rating? A strong three (3) stars at best in my eyes. This is not for a tough chewer. I have to constantly monitor its condition. It does succeed as a tug toy, but it has more limitations that I was expecting. I hope my thoughts added a bit of information.
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Reviewed in the United States on March 28, 2026
L
Verified Purchase
Liz. W
Bozeman, US
★★★★★ 5
Long lasting
Size: 5 in
Love these. My dogs are aggressive chewing and these last the longest.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 25, 2025
A
Verified Purchase
Adrianna
Battle Creek, US
★★★★★ 5
Bully proof?!
Size: 5 in
We have the cutest little pit/lab mix who destroys stuffed toys in about two seconds flat. It’s always a HUNT to find toys he won’t instantly shred. This brand has some of the best! They were in FiveBelow for a while and it was the only brand that stood up to him initially. He finally got through the first only after MONTHS so we bought a few back ups and they’re still going strong months later! They’re also not super heavy so these end up being the toys we play fetch with most often! 100% will be buying more in this line in the future!
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Reviewed in the United States on June 15, 2024

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