SKU: 5942088976

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

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Description

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsulesFolate is a vital B vitamin that plays a key role in methylationa critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.* Why Quatrefolic? Quatrefolic is the glucosamine salt of (6S) 5 methyltetrahydrofolatethe

Folate is a vital B vitamin that plays a key role in methylation—a critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic®, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.*

Why Quatrefolic®?

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate—the bioactive form of folate that the body uses directly, without requiring conversion. Unlike folic acid, which must go through multiple enzymatic steps to become active, Quatrefolic® is ready for immediate uptake and use at the cellular level.*

  • Clinically studied for enhanced bioavailability
  • Supports methylation pathways*
  • Supports healthy homocysteine balance*
  • Supports mood and cardiovascular health*
  • Essential for fetal development and reproductive health*

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Who It's For

This high-dose formula is ideal for individuals with increased folate needs or those with MTHFR gene variants who may have trouble converting folic acid to its usable form.*

How It Works

Folate is required to convert homocysteine into methionine—a process vital for cardiovascular and neurological function. It also supports the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which influence mood and cognition.*

What Makes Ours Better?

  • Longevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
  • Triple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
  • Complete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body. 
  • USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
  • 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

1 Bani Soheila, J Caring Sci 2013 
2 Mazza A. et al. Biol Regul Homeost Agents 2016
3 Rima Obeid R., Herrmann W. FEBS Letters 580, 2006
4 Stover Patrick, Curr Opin Biotechnol 2017
Seshadri S. at al. N Engl J Med 2002 
6 Bottiglieri T, J Neurol Neurosurg Psychiatry 2000 
7 Thaler C.J. 2014 
8 Stover PJ. Modern Nutrition in Health and Disease 2012
9 Tinelli C, Di Pino A Front. Nutr. 2019

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolate, glucosamine salt) 25000 mcg DFE (15 mg) 6250%
* Daily Value (DV) based on a 2,000 calorie diet.
REV. 03.24
  • OTHER INGREDIENTS: Microcrystalline cellulose, vegetable capsule.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 capsule daily, or as directed by your healthcare professional.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. 
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
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  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 5942088976

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4.9 ★★★★★
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Brandy B
Houston, US
★★★★★ 5
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This chew toy has quickly become our puppy’s absolute favorite. She’s just starting to teethe, and keeping her busy and comfortable has definitely been a challenge, but this ring has been a lifesaver. She was interested in it right away and keeps coming back to it on her own, which is a huge win. The chicken flavor seems to really hold her attention, and it gives her something appropriate to chew instead of everything else. It’s the perfect size for a very young puppy and easy for her to hold and gnaw on without getting frustrated. It keeps her occupied, helps soothe her gums, and gives us a much-needed break during those teething moments. If you have a puppy just starting the teething phase and need something safe, durable, and engaging, this is an excellent choice and one I’d happily buy again.
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Reviewed in the United States on February 6, 2026
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Ginger Murdough
Houston, US
★★★★★ 5
Nylabone Ring Bone
Size: X-Small, Color: Ring Bone
My dog loves these. She chews them into pieces which helps keep her teeth clean. It is a mess to clean up. She chews and spits out the pieces. She is 6 years old so not a puppy.
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Reviewed in the United States on May 29, 2026
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Michelle Kim
Waukegan, US
★★★★★ 4
Everything a Teething Puppy Could Need — Well-Thought-Out Kit
Size: X-Small, Color: Teething Bone
The Nylabone New Puppy Starter Kit is a solid all-in-one solution for the first few months of puppy ownership. It comes with multiple chew toys and bones designed specifically for teething puppies, and my little one took to them right away. The variety keeps him engaged, and I appreciate that each item is designed to be gentle on developing teeth while still satisfying his urge to chew. What differentiates this kit from other puppy chew sets on Amazon is the thoughtful selection of textures and shapes. It’s clear these toys are designed to stimulate gums, promote healthy chewing habits, and even support dental care. I also like that everything is non-toxic and durable enough to survive a few enthusiastic chews. The only reason I didn’t give 5 stars is that the kit might be a bit small for larger breeds, or for puppies that are particularly aggressive chewers. But for standard small to medium pups, it’s a fantastic starter kit that keeps both puppy and owner happy. ✅ Bottom line: A reliable, well-designed starter kit for teething puppies which is thoughtful, durable, and engaging. Makes a great gift for new puppy owners or a practical addition to your own puppy’s toy collection.
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Reviewed in the United States on September 26, 2025
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Valarie Amundsen
West Palm Beach, US
★★★★★ 5
Chew
Size: X-Small, Color: Ring Bone
My dog loves this little chewy bone and it’s good for her teeth. That was very cheap on a sale. It’s worth giving it a try highly recommend it.
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Reviewed in the United States on June 11, 2026
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princeton von d
Waukegan, US
★★★★★ 3
Chicken Flavor Good, But 🔄 Rotation-Resistant✖; Best for Simpler Chewers
Size: X-Small, Color: Ring Bone, Size: X-Small, Color: Ring Bone
🐾 Hi, I’m PVD; plush sophisticate, chew critic, and active curator of rotational toy relevance. This ring bone and I never fully bonded. I sampled it maybe five times in my entire puppyhood before quietly returning it to the bin (with a single judgmental glance). Still, it does have value for the right pup. ⭐ Why I originally wanted to love it: ✔️ XS size works well for very young puppies ✔️ Chicken flavor lasts impressively long ✔️ Freezing offers temporary gum relief ✔️ Durable and safe; no odd odors or shredding 🌀 Why it’s now a respectful 3-star chew in my rotation: ✘ Never became a go-to toy (5 uses max in my life) ✘ Ring shape felt awkward, not natural or chic; hard to grip and maneuver ✘ Texture too tame vs. nubs or detailed chew surfaces ✘ When I was smaller, I much preferred the Nylabone Baby Blue Bone Chew Toy with nubs (my personal classic), and have since matured into nightly Nylabone “Nubz” edible bones This Ring Bone is Best For: • Very young puppies with minimal chew preferences • Dogs who like simple textures and circular shapes • Those just starting enrichment chew play • Freezer treat rotations (briefly) 🚫 Not ideal for: picky pups, advanced chewers, or dogs who analyze toy ergonomics (like myself). 📝 Final Re-Barks: A strong, well-made chew, but lacked the intrigue to make my permanent rotation. Works for basic chew enjoyment; not for pups with elevated taste or toy ambition. — PVD (Chew Strategist, Textural Analyst & Aspire-to-Vine Reviewer 🐶💼)
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Reviewed in the United States on September 17, 2025

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