SKU: 70534438192

UltraFlora Healthy Weight with Akkermansia

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Description

UltraFlora Healthy Weight with AkkermansiaResearch Highlights UltraFlora Healthy Weight with Akkermansia (Formerly Akkermansia muciniphila) is a keystone species inhabiting host intestinal mucus layer and contributes to the maintenance of a healthy gut barrier. A lower abundance of Akkermansia muciniphila is associated with poor metabolic health, whereas a higher abundance is linked to better metabolic health. Its membrane protein Amuc_1100 can help maintain host gut barrier integrity,

Research Highlights
UltraFlora Healthy Weight with Akkermansia (Formerly Akkermansia muciniphila) is a keystone species inhabiting host
intestinal mucus layer and contributes to the maintenance of
a healthy gut barrier.
A lower abundance of Akkermansia muciniphila is associated
with poor metabolic health, whereas a higher abundance is
linked to better metabolic health.
Its membrane protein Amuc_1100 can help maintain host
gut barrier integrity, support immune homeostasis, and
improve metabolic functions via TLR2 signaling. Amuc_1100
remains active after pasteurization.
A human clinical trial demonstrated that pasteurized
Akkermansia muciniphila is more effective than the live
bacterium in improving metabolic health-related parameters.

A unique, mucin-loving keystone species
The gut mucus layer forms a natural defense barrier, and its integrity
is vital for maintaining the intestinal health of the host.1 Akkermansia
muciniphila, unlike many of the known probiotic species, is a unique
commensal microbe inhabiting the mucus layer, where it can
interact closely with host intestinal epithelial cells and immune cells.
Akkermansia muciniphila is known to utilize mucins (key components
of mucus) as nutrient and energy sources and produce beneficial
short-chain fatty acids (SCFAs).2

It is believed that through reinforcing
gut barrier function, Akkermansia muciniphila supports various bodily
functions, such as energy, lipid, and glucose metabolism as well as
immune responses.3
Clinical relevance of Akkermansia muciniphila
The presence and abundance of Akkermansia muciniphila in the gut
may be indicative of the host’s metabolic health:4
• In multiple human cohort studies, the abundance of Akkermansia
muciniphila is reduced in the microbiomes of individuals with
obesity, type 2 diabetes (T2DM), impaired glucose control, high
blood pressure, inflammatory bowel diseases, and liver diseases
(Figure 1).5-10
• Conversely, greater abundance of Akkermansia muciniphila is
linked with a leaner body weight, lower body fat mass, and greater
improvement in insulin sensitivity (Figure 1).5,11

Science Review

Proposed mechanisms of actions of Akkermansia
muciniphila
Recent intervention studies in animals demonstrated Akkermansia
muciniphila administration reversed high-fat diet-induced metabolic
disorders, fat-mass gain, metabolic endotoxemia, adipose tissue
inflammation, and insulin resistance.12 As seen in Figure 2, Akkermansia
muciniphila has been demonstrated to exert several mechanisms of action
such as:
• Enhance mucin production by increasing the number and density of
goblet cells (mucin-producing cells), which helps restore the thickness
of the mucus layer.13
• Increase the expression of tight-junction proteins within the intestinal
epithelium to augment the integrity of tight junctions.14
• Its membrane protein Amuc_1100 binding to Toll-like receptor 2 (TLR2),
leading to activation of anti-inflammatory pathways, prevention of
lipopolysaccharides (LPS) translocation, and improvement in mucin
secretion and gut barrier.15
More important, researchers discovered that mice receiving pasteurized
Akkermansia muciniphila had a greater reduction in body weight, fat-mass
gain, plasma lipids, and insulin-resistance markers than mice receiving the
live bacterium.15 Research found that the protein Amuc_1100 remained
heat-stable after pasteurization, and its administration alone recapitulated
most of the observed metabolic benefits in vivo. This suggests that
pasteurization enhances the effects of Akkermansia muciniphila by
increasing accessibility of Amuc_1100 to the host.15

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SKU: 70534438192

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patriciakeyes
Dallas, US
★★★★★ 5
A size easy to swallow
Size: 80 Count (Pack of 1)
Great product and finally the size that is easy to swallow.
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Reviewed in the United States on April 2, 2026
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DH
New York, US
★★★★★ 5
Dropped LDL by 38 at one year check up
Size: 60 Count (Pack of 1)
I am a 48 year old female weighing 126 lbs. I want to praise this product for reducing cholesterol levels. I have seen the cardiologist to be proactive since my dad died of heart disease and because it runs on both sides of the family. My cholesterol levels have been borderline high for several years but not to the point of needing medication. In April 2025 it was the highest levels so far. I had been eating healthy cereals and exercising at that time so I was surprised it had increased. I have taken this supplement daily for a full year without missing many doses. I just had my yearly check up on April 1, 2026, and my total cholesterol dropped by 37 and the bad LDL dropped by 38. I am very please with my results. All my levels were in the optimal range except the LDL and It was in the nearly optimal range per the Labcorp graph and total cholesterol was in the acceptable range. I have not exercised in 8 months and I eat a lot of fast food, so this product is the only explanation for the improvement. I also started the Megared CoQ10 about 5 weeks before my labs but it wouldn't be long enough to be that helpful yet. I am going to stay on the CoQ10 in addition to the Megared 4 in 1 product to see if it further lowers the LDL to the optimal range next year. In one year with no diet changes or exercise: Cholesterol total went from 228 to 191 LDL Cholesterol went from 161 to 123 The only thing I do not like about the product is the price but with those results I can't complain. It is worth it.
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Reviewed in the United States on April 3, 2026
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ERICKA F SALAZAR
Alexandria, US
★★★★★ 5
Excelente producto
Size: 80 Count (Pack of 1)
Es muy buen producto! Ya es la segunda vez que los compro y me ayudado muchísimo.
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Reviewed in the United States on June 3, 2026
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Patrick Wihler
Port Orchard, US
★★★★★ 5
MegaRed Omega Fish Oil
Size: 80 Count (Pack of 1)
Great Fish Oil
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Reviewed in the United States on May 28, 2026
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Michael martinez
Lowell, US
★★★★★ 5
Stay healthy
Good pill size, and new lemon flavor. Has all the great omega Three, and fish oil for brain, heart and joints. Good price and quality. Easy to swallow with no bad burping as long as you keep it refrigerated. Works fast and is a great choice.
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Reviewed in the United States on May 27, 2026

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