SKU: 71228785598

Vitamin B-12 - 5000 mcg, 120 lozenges

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Description

Vitamin B-12 - 5000 mcg, 120 lozengesBenefits: Introducing ProHealth Longevity's Vitamin B12, a unique combination crafted to harness the synergistic benefits of multiple forms of Vitamin B12. This innovative formula incorporates methylcobalamin, dibencozide, cyanocobalamin, and hydroxycobalamin, each selected for their unique contributions to cellular health, energy metabolism, and overall longevity. While many B12 supplements focus solely on one form of B12, ProHealth Longevity's

Benefits:

Introducing ProHealth Longevity's Vitamin B12, a unique combination crafted to harness the synergistic benefits of multiple forms of Vitamin B12. This innovative formula incorporates methylcobalamin, dibencozide, cyanocobalamin, and hydroxycobalamin, each selected for their unique contributions to cellular health, energy metabolism, and overall longevity. While many B12 supplements focus solely on one form of B12, ProHealth Longevity's Vitamin B12 embraces a comprehensive approach, recognizing the diverse roles and benefits offered by each variant. From supporting brain function to enhancing energy levels and combating age-related declines, our formula is designed to optimize B12 status and promote vitality at every stage of life.

  • Plays a crucial role in maintaining cellular integrity by aiding in DNA synthesis and repair
  • Acts as a cofactor in the conversion of carbohydrates, fats, and proteins into usable energy
  • Supports healthy brain aging by aiding in the regeneration of myelin, the protective sheath around nerve fibers
  • Provides mood support by serving as a cofactor in the synthesis of neurotransmitters

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Research-Supported Benefits:

Enhances cellular health. Vitamin B12 is a pivotal player in the synthesis and repair of DNA, critical processes that safeguard cellular integrity. Research has linked Vitamin B12 deficiency to disruptions in DNA synthesis and repair mechanisms, underscoring its importance in maintaining genetic stability. (1) Vitamin B12 offers further cellular protection by supporting telomere maintenance, the protective caps at the ends of chromosomes. Telomeres play a vital role in preserving DNA integrity during cell division, and their maintenance is closely linked to longevity and overall health. By supporting telomere integrity and DNA repair mechanisms, Vitamin B12 contributes to enhanced cellular resilience and longevity, offering comprehensive support for optimal aging.

Heathy heart aging: Vitamin B12 aids in the reduction of homocysteine levels, an amino acid implicated in various forms of DNA damage, including DNA strand breaks. Elevated homocysteine is associated with accelerated cardiovascular aging and increased risk of cardiovascular events. (2) Research shows that increasing vitamin B12 intake may reduce homocysteine levels up to 7%. (3)

Promotes energy production. Vitamin B12 is indispensable for sustaining energy levels, with its deficiency linked to reduced energy production in the body. Through its involvement in synthesizing SAMe, a vital methyl donor nutrient, Vitamin B12 supports mitochondrial function and the generation of ATP, the primary energy currency of cells. As we age, ATP production tends to decline, exacerbated by decreasing levels of Vitamin B12. This decline can lead to age-related fatigue and diminished stamina. Supplementation with Vitamin B12 may offer a solution by replenishing stores and potentially mitigating the decline in ATP production associated with aging.

Promotes Cognitive Health. Vitamin B12 plays a crucial role in maintaining cognitive function, and its deficiency is strongly associated with cognitive decline and memory impairment. (4) Its diverse functions in methylation, neurotransmitter synthesis, and mitochondrial activity are essential for optimal brain health. Notably, Vitamin B12 shows promise in mitigating age-related neurodegeneration by regulating inflammatory processes and protecting against the formation of amyloid beta (Aβ) plaque. (5) Supplementation with Vitamin B12 has potential to alleviate symptoms linked to accelerated brain aging and support overall cognitive well-being.

Supports Mood. Vitamin B12 plays a vital role in the synthesis of essential mood-regulating neurotransmitters, including serotonin and dopamine. Serotonin, known as the "feel-good" neurotransmitter, is synthesized from the amino acid tryptophan in a process facilitated by SAMe, which in turn relies on sufficient levels of Vitamin B12 for optimal function. Similarly, dopamine, a neurotransmitter linked to reward, pleasure, and motivation, also depends on Vitamin B12 for its synthesis. Scientific studies have demonstrated that deficiency in Vitamin B12 correlates with mood dysregulation, contributing to symptoms such as irritability and personality changes. (6)

References:

1. Alzoubi KH, Bayraktar E, Khabour O, Al-Azzam SI. Vitamin B12 protects against DNA damage induced by hydrochlorothiazide. Saudi Pharm J. 2018;26(6):786-789. doi:10.1016/j.jsps.2018.04.005

2. Yan Y, Yin Y, Feng X, et al. Homocysteine aggravates DNA damage by impairing the FA/Brca1 Pathway in NE4C murine neural stem cells. Int J Med Sci. 2020;17(16):2477-2486. Published 2020 Sep 9. doi:10.7150/ijms.49246

3. Maruyama K, S Eshak E, Kinuta M, et al. Association between vitamin B group supplementation with changes in % flow-mediated dilatation and plasma homocysteine levels: a randomized controlled trial. J Clin Biochem Nutr. 2019;64(3):243-249. doi:10.3164/jcbn.17-56

4. Jatoi S, Hafeez A, Riaz SU, Ali A, Ghauri MI, Zehra M. Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020;12(2):e6976. Published 2020 Feb 13. doi:10.7759/cureus.6976

5. Lam AB, Kervin K, Tanis JE. Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle. Cell Rep. 2021;36(13):109753. doi:10.1016/j.celrep.2021.109753

6. Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depre**ion. Cureus. 2020;12(10):e11169. Published 2020 Oct 26. doi:10.7759/cureus.11169

  • When taken as a supplement, Vitamin B12 is released in the stomach and binds to intrinsic factor, a protein produced by the stomach lining.
  • The Vitamin B12-intrinsic factor complex travels to the small intestine, where it is absorbed into the bloodstream through specialized receptors in the intestinal lining.
  • Once in the bloodstream, Vitamin B12 is transported to various tissues and cells throughout the body, where it exerts its functions.
  • Vitamin B12 plays a crucial role in energy metabolism as a cofactor for the enzyme methionine synthase, which helps convert homocysteine to methionine. Methionine serves as a precursor for S-adenosylmethionine (SAMe), a key methyl donor in cellular reactions.
  • SAMe participates in methylation reactions essential for ATP synthesis, the primary energy currency of cells, thus contributing to overall energy production and vitality.
  • Vitamin B12 helps maintain mitochondrial health and facilitates neurotransmitter synthesis, promoting youthful cognitive functioning and reducing the risk of age-related cognitive decline.
  • Vitamin B12 is crucial for brain health and cognitive function, as it supports mitochondrial function and neurotransmitter synthesis. Mitochondria in brain cells require Vitamin B12 for energy production, which is essential for maintaining neuronal activity and cognitive processes.
Supplement Facts
Serving Size: 1 Lozenge
Servings Per Container: 120
Amount Per Serving %DV
Vitamin B12 5000 mcg 208333%
  Methylcobalamin 1786 mcg 74417%
  Dibencozide 1786 mcg 74416%
  Cyanocobalamin 1071 mcg 44625%
  Hydroxycobalamin 357 mcg 14875%
% Daily Values are based on a 2,000 calorie diet

REV. 12.23

  • OTHER INGREDIENTS: Sorbitol, natural strawberry flavor, rice extract blend, natural color (grape skin extract), and silicon dioxide.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 lozenge daily, allow lozenge to fully dissolve under your tongue, then swallow, or as recommended by your healthcare professional.
  • NOTE: Natural color variation may occur. Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Optimize B12 Status. ProHealth’s Vitamin B12 was specifically formulated to reduce symptoms of age-related health decline associated with low vitamin b12 levels.
  • Unique Combination: Compared to other supplement brands using isolated forms of vitamin b12 ProHealth’s Vitamin B12 contains four different forms of vitamin B12, each selected for their unique contributions to cellular health, energy metabolism, and overall longevity.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 71228785598

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4.7 ★★★★★
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KAB
Alexandria, US
★★★★★ 5
Great Read!!! Great story!!!
Format: Kindle
The series is long, but Ms. Wolfhart does a fantastic job of weaving this tale while bringing so much to the characters. Surprises and plot twists along the way to keep you intrigued. There is some graphic sex, but is no way the focal point. Grammar was excellent (a rare find with a lot of self publishers) with only a few noted errors. I rarely give 4 stars, let alone 5.
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Reviewed in the United States on April 30, 2021
E
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Elisa
Cuba, US
★★★★★ 3
Sadly, DNF
Format: Kindle
I read this thru KU. I LOVED the synopsis. And then I began reading... and it was a DNF at 68% after picking it up and putting it down several times because I really loved the main female character. *****SPOILERS***** Pros: The world is unique, intriguing and fun. The primary female character is bad-a** but not a b*tech or a mary sue. The primary female has depth. I really want to know what happens to her even tho it's been weeks and I don't remember her name. The villains to the point I read are pretty good -- an ever present threat of mysterious and possibly many culprits. Cons: Way, way too many points of view. I stopped counting at 7. It's the prime reason why I don't care about most of the characters or remember their names even when I like them. There's just too many points of view so almost none of the characters have enough book space for the author to properly develop them. This literally killed the book for me. Actually it killed my desire to read. For weeks. The main male is more villain than hero. He agreed to marry the main female then locks her up & eschews her for her sister, all while bad mouthing her as unfit to rule when he never spent any time with her getting to know her. He is actually unfit to rule as he is blind to the woes of his own kingdom and starts off a peace mission to secure a ceasefire through marriage by murdering an inn full of people in her country for no real reason. Plus, he constantly makes promises he does not keep. And it's gross of him to pine for the sister behind the main female's back. ***** As much as I really wanted to see what happened to the main female character, it wasn't enough for me to keep trying to slog thru this book. There was a lot of potential here that just fell short. Hence, 3 stars.
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Reviewed in the United States on June 19, 2021
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MaryBeth K
Grantham, US
★★★★★ 5
Fae Courts with High Intrigue
Format: Kindle
This book is one that just builds and builds and then surprises you to no end. You may think you know the villains and then you are jolted in another direction. Princess Reyna is a real gem, strong of character, a fierce fighter, and loyal to her family and kingdom. Just when you think she and Lorcan, well you know, the plot is flipped. Can't wait to see where this goes in book two.
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Reviewed in the United States on July 7, 2023
K
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Kindle Customer Maureen
Waukegan, US
★★★★★ 4
Slow, sorry but good
Format: Kindle
This was a slow moving book. Lots of character pov chapters, lots of superfluous descriptions and endless courtly appearances stalled this book to start. Once you get into the heart of the story, it takes off. Before you know it the book is done. My favorite character is Reyna. She is so strong. She is true to herself. She gets into a lot of trouble with her headstrong ways but it's entertaining. I have high hopes for Lorcan. He is honorable to a fault. Thane had turned out to be better than I thought but i still don't like him. Eislin is useless. Great plot twists at the end. I'm looking forward too book 2.
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Reviewed in the United States on June 6, 2020
F
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Faifre6
West Palm Beach, US
★★★★★ 5
Very detailed! Beautiful world building! Strong Heroine!
Format: Kindle
Starts off a little slow and confusing with different POV’s, but starts to all come together towards the middle to make an elaborate plot line and makes it all worth it. Beautiful world building and attention to detail as well as great writing. The cliffhanger was gut wrenching! Can’t wait for the next book!
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Reviewed in the United States on March 4, 2020

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