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Description
FITC-Labeled CD20 Flag&His Tag Full Length Protein, Human(Detergent)Product Specification Species Human Synonyms B lymphocyte surface antigen B1,MS4A1,B lymphocyte antigen CD20,Membrane Spanning 4 Domains A1,Leukocyte Surface Antigen Leu 16,CD20 Antigen,CD20,Bp35,Membrane Spanning 4 Domains Subfamily A Member 1,CD20 Receptor,LEU 16,CVID5,MS4A2,B1,S7,Antigens,CD20,Membrane Spanning 4 Domains,Subfamily A,Member 1,B Lymphocyte Cell Surface Antigen B1 Accession P11836 Amino Acid Sequence Full length, with Flag tag at N
Product Specification
| Species | Human |
| Synonyms | B-lymphocyte surface antigen B1,MS4A1,B-lymphocyte antigen CD20,Membrane Spanning 4-Domains A1,Leukocyte Surface Antigen Leu-16,CD20 Antigen,CD20,Bp35,Membrane-Spanning 4-Domains Subfamily A Member 1,CD20 Receptor,LEU-16,CVID5,MS4A2,B1,S7,Antigens,CD20,Membrane-Spanning 4-Domains,Subfamily A,Member 1,B-Lymphocyte Cell-Surface Antigen B1 |
| Accession | P11836 |
| Amino Acid Sequence | Full length, with Flag tag at N-Terminal, and His tag at C-Terminal |
| Expression System | HEK293 |
| Molecular Weight | 35.4 kDa |
| Conjugation | FITC |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 25mM Hepes 150mM NaCl 0.02%DDM |
| Stability & Storage |
·6 months from date of receipt, -60 to -80 °C as supplied. |
| Reference | 1. Rougé L, Chiang N, Steffek M, et al. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab[J]. Science, 2020, 367(6483): 1224-1230. |
Background
CD20 is a 33-37 kDa non-glycosylated protein present on the surface of normal and malignant B lymphocytes and is a member of the MS4A (membrane-spanning 4-domain family A) protein family. The CD20 protein comprises four hydrophobic transmembrane domains, one intracellular domain, and two extracellular domains (a large loop and a small loop), with both the N- and C-termini located within the cytosol. CD20 is associated with several key molecules, including the major histocompatibility complex class II (MHCII), CD40 molecule, B-cell receptor (BCR), and the C-terminal src kinase-binding protein (CBP). CBP interacts with Src kinases such as LYN, FYN, and LCK.
A deficiency in CD20 has been shown to result in a reduced number of circulating memory B cells, decreased isotype switching of immunoglobulins (Ig), and lower IgG antibody levels. It is also linked to various pathophysiological diseases and disorders.
CD20 plays a crucial role in multiple physiological processes and is thus a promising therapeutic target. The CD20 protein product has the potential to enhance drug discovery efforts in related fields.
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