Protect +5 - 60 Capsules

Protect +5 - 60 CapsulesProtect+5 Comprehensive Fat Soluble Vitamin and Nutrient Absorption Support Balanced Protection for Bone, Heart, and Immune Health Protect+ is a next generation formula designed to support the optimal balance, absorption, and biological activity of key fat soluble vitamins essential for long term health. Combining clinically validated, bioavailable forms of Vitamins K2 (MK 7), D3, A, and E with AstraGin, Protect+ helps promote bone strength,

Protect+5 — Comprehensive Fat-Soluble Vitamin and Nutrient Absorption Support

Balanced Protection for Bone, Heart, and Immune Health

Protect+ is a next-generation formula designed to support the optimal balance, absorption, and biological activity of key fat-soluble vitamins essential for long-term health.
Combining clinically validated, bioavailable forms of Vitamins K2 (MK-7), D3, A, and E with AstraGin®, Protect+ helps promote bone strength, cardiovascular wellness, immune balance, and antioxidant protection— while ensuring maximum nutrient utilization.

Featured Benefits

• Supports healthy calcium utilization for bones, teeth, and cardiovascular integrity*

• Promotes balanced immune and cellular function*

• Provides broad-spectrum antioxidant defense*

• Encourages optimal absorption and bioavailability of fat-soluble vitamins*

• Supports healthy aging and metabolic vitality*

Vitamin K2 (MK-7 as K2VITAL® Delta) — 300 mcg

Vitamin K2 (MK-7) activates key proteins involved in calcium metabolism, helping direct calcium to bones and away from soft tissues.*
Protect+ features K2VITAL® Delta, a double micro-encapsulated, >99% all-trans bioactive form of MK-7 for superior stability, bioavailability, and potency.
Among all K-vitamins, MK-7 offers the longest half-life and best tissue distribution, supporting skeletal strength, vascular flexibility, and cellular energy pathways.

Vitamin D3 — 125 mcg (5,000 IU)

Vitamin D3 is essential for calcium absorption, bone integrity, immune function, and cellular resilience. It supports healthy gene expression and cellular signaling pathways associated with longevity, metabolic efficiency, and a balanced inflammatory response.

Vitamin A 

Vitamin A (retinol) plays a central role in cell differentiation, tissue renewal, immune function, and visual health. It also contributes to skin integrity and mucosal barrier function and acts as an antioxidant nutrient that helps maintain cellular health during oxidative stress.

Vitamin E 

Vitamin E is a potent lipid-soluble antioxidant that protects cell membranes from oxidative damage and helps maintain red blood cell integrity.
It also supports the stability of other fat-soluble nutrients, including vitamins A and C, enhancing their biological efficacy.

AstraGin® — Bioavailability Optimizer

Derived from Panax notoginseng and Astragalus membranaceus, AstraGin® has been shown in over a dozen in-vitro studies to support nutrient absorption and cellular uptake.
It promotes improved transport of vitamins, amino acids, and peptides through intestinal pathways, optimizing bioavailability and nutrient efficiency.

References:

Vitamin K2 MK-7:

• Lal N, Berenjian A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Appl Microbiol Biotechnol. 2020 Apr;104(7):2765-2776. doi: 10.1007/s00253-020-10409-1. Epub 2020 Feb 3. PMID: 32009201.
• Sato T, Inaba N, Yamashita T. MK-7 and Its Effects on Bone Quality and Strength. Nutrients. 2020 Mar 31;12(4):965. doi: 10.3390/nu12040965. PMID: 32244313; PMCID: PMC7230802.
• Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037.
• Simes DC, Viegas CSB, Araújo N, Marreiros C. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci. 2019 Aug 25;20(17):4150. doi: 10.3390/ijms20174150. PMID: 31450694; PMCID: PMC6747195.
• Pisoschi AM, Pop A, Iordache F, Stanca L, Geicu OI, Bilteanu L, Serban AI. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur J Med Chem. 2022 Mar 15;232:114175. doi: 10.1016/j.ejmech.2022.114175. Epub 2022 Feb 4. PMID: 35151223; PMCID: PMC8813210.

Vitamin D: 

• Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019 Jun;60(3):237-244. doi: 10.1016/j.pedneo.2019.04.007. Epub 2019 Apr 17. PMID: 31101452.
• Martens PJ, Gysemans C, Verstuyf A, Mathieu AC. Vitamin D's Effect on Immune Function. Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390/nu12051248. PMID: 32353972; PMCID: PMC7281985.
• Ao T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021 Nov 3;11(11):1624. doi: 10.3390/biom11111624. PMID: 34827621; PMCID: PMC8615708.
• Abiri B, Vafa M. Vitamin D and Muscle Sarcopenia in Aging. Methods Mol Biol. 2020;2138:29-47. doi: 10.1007/978-1-0716-0471-7_2. PMID: 32219739.

Vitamin A:

• Bar-El Dadon S, Reifen R. Vitamin A and the epigenome. Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2404-2411. doi: 10.1080/10408398.2015.1060940. PMID: 26565606.
• Conaway HH, Henning P, Lerner UH. Vitamin a metabolism, action, and role in skeletal homeostasis. Endocr Rev. 2013 Dec;34(6):766-97. doi: 10.1210/er.2012-1071. Epub 2013 May 29. PMID: 23720297.
• Stephensen CB, Lietz G. Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. Br J Nutr. 2021 Dec 14;126(11):1663-1672. doi: 10.1017/S0007114521000246. Epub 2021 Jan 20. PMID: 33468263; PMCID: PMC7884725.
• Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol. 2019 Apr;54(2):184-192. doi: 10.1080/10409238.2019.1611734. Epub 2019 May 14. PMID: 31084433; PMCID: PMC6629036.

Vitamin E: 

• Pekmezci D. Vitamin E and immunity. Vitam Horm. 2011;86:179-215. doi: 10.1016/B978-0-12-386960-9.00008-3. PMID: 21419272.
• Casati M, Boccardi V, Ferri E, Bertagnoli L, Bastiani P, Ciccone S, Mansi M, Scamosci M, Rossi PD, Mecocci P, Arosio B. Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clin Exp Res. 2020 Mar;32(3):459-464. doi: 10.1007/s40520-019-01209-3. Epub 2019 May 3. PMID: 31054115.
• Corina A, Rangel-Zúñiga OA, Jiménez-Lucena R, Alcalá-Díaz JF, Quintana-Navarro G, Yubero-Serrano EM, López-Moreno J, Delgado-Lista J, Tinahones F, Ordovás JM, López-Miranda J, Pérez-Martínez P. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study. J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):770-777. doi: 10.1093/gerona/gly195. PMID: 30165472.
• Moriguchi S, Muraga M. Vitamin E and immunity. Vitam Horm. 2000;59:305-36. doi: 10.1016/s0083-6729(00)59011-6. PMID: 10714244.

AstraGin®:

• Chang, Tsu-Chung et al. “Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.” Journal of agricultural and food chemistry vol. 55,5 (2007): 1993-8. doi:10.1021/jf062714k

• During A, Harrison EH. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res. 2007 Oct;48(10):2283-94. doi: 10.1194/jlr.M700263-JLR200. Epub 2007 Jul 20. PMID: 17644776.
• Reboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier JF, Jourdheuil-Rahmani D, Dufour C, Collet X, Borel P. Vitamin D intestinal absorption is not a simple passive diffusion: evidence for involvement of cholesterol transporters. Mol Nutr Food Res. 2011 May;55(5):691-702. doi: 
• Reboul E. Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte. IUBMB Life. 2019 Apr;71(4):416-423. doi: 10.1002/iub.1955. Epub 2018 Oct 11. PMID: 30308094.

Caution: Individuals taking more than 50 mcg (2,000 IU) of Vitamin D per day should have their vitamin D levels monitored. This product is not intended for long term use and should be used under the supervision of your doctor.